Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess pot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1095211/full |
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| author | Tarek Arabi Areez Shafqat Belal Nedal Sabbah Nader Ashraf Hassan Shah Humzah Abdulkader Adhil Razak Ahmad Nedal Sabbah Ziad Arabi Ziad Arabi Ziad Arabi |
| author_facet | Tarek Arabi Areez Shafqat Belal Nedal Sabbah Nader Ashraf Hassan Shah Humzah Abdulkader Adhil Razak Ahmad Nedal Sabbah Ziad Arabi Ziad Arabi Ziad Arabi |
| author_sort | Tarek Arabi |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting a myriad of cytokines and adipokines that contribute to insulin resistance and induce a chronic low-grade inflammatory state thereby damaging the kidney. CKD development itself is associated with various metabolic alterations that exacerbate adipose tissue dysfunction and insulin resistance. This adipose-renal axis is a major focus of current research, given the rising incidence of CKD and obesity. Cellular senescence is a biologic hallmark of aging, and age is another significant risk factor for obesity and CKD. An elevated senescent cell burden in adipose tissue predicts renal dysfunction in animal models, and senotherapies may alleviate these phenotypes. In this review, we discuss the direct mechanisms by which adipose tissue contributes to CKD development, emphasizing the potential clinical importance of such pathways in augmenting the care of CKD. |
| format | Article |
| id | doaj-art-eda2d8273b764b5689fb5f4ecc090b49 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-eda2d8273b764b5689fb5f4ecc090b492025-08-20T02:27:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10952111095211Obesity-related kidney disease: Beyond hypertension and insulin-resistanceTarek Arabi0Areez Shafqat1Belal Nedal Sabbah2Nader Ashraf3Hassan Shah4Humzah Abdulkader5Adhil Razak6Ahmad Nedal Sabbah7Ziad Arabi8Ziad Arabi9Ziad Arabi10College of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaDivision of Nephrology, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Riyadh, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaChronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting a myriad of cytokines and adipokines that contribute to insulin resistance and induce a chronic low-grade inflammatory state thereby damaging the kidney. CKD development itself is associated with various metabolic alterations that exacerbate adipose tissue dysfunction and insulin resistance. This adipose-renal axis is a major focus of current research, given the rising incidence of CKD and obesity. Cellular senescence is a biologic hallmark of aging, and age is another significant risk factor for obesity and CKD. An elevated senescent cell burden in adipose tissue predicts renal dysfunction in animal models, and senotherapies may alleviate these phenotypes. In this review, we discuss the direct mechanisms by which adipose tissue contributes to CKD development, emphasizing the potential clinical importance of such pathways in augmenting the care of CKD.https://www.frontiersin.org/articles/10.3389/fendo.2022.1095211/fullchronic kidney diseaseobesitycellular senescencechronic inflammationadipokinessenotherapies |
| spellingShingle | Tarek Arabi Areez Shafqat Belal Nedal Sabbah Nader Ashraf Hassan Shah Humzah Abdulkader Adhil Razak Ahmad Nedal Sabbah Ziad Arabi Ziad Arabi Ziad Arabi Obesity-related kidney disease: Beyond hypertension and insulin-resistance Frontiers in Endocrinology chronic kidney disease obesity cellular senescence chronic inflammation adipokines senotherapies |
| title | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
| title_full | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
| title_fullStr | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
| title_full_unstemmed | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
| title_short | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
| title_sort | obesity related kidney disease beyond hypertension and insulin resistance |
| topic | chronic kidney disease obesity cellular senescence chronic inflammation adipokines senotherapies |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1095211/full |
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