Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2,...

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Bibliographic Details
Main Authors: Nisreen M. A. Okba, Ivy Widjaja, Brenda van Dieren, Andrea Aebischer, Geert van Amerongen, Leon de Waal, Koert J. Stittelaar, Debby Schipper, Byron Martina, Judith M. A. van den Brand, Martin Beer, Berend-Jan Bosch, Bart L. Haagmans
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Vaccine
MERS-coronavirus
spike
i301
lumazine synthase
spytag-spycatcher
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1760735
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