A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination

A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination

Abstract Intrahepatic cholangiocarcinoma (ICC), a formidable challenge in oncology, demands innovative biomarkers and therapeutic targets. This research highlights the importance of the circular RNA (circRNA) circPCSK6 and its peptide derivative circPCSK6‐167aa in ICC. CircPCSK6 is significantly dow...

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Main Authors: Canghai Guan, Jianjun Gao, Xinlei Zou, Wujiang Shi, Yunhe Hao, Yifei Ge, Zhaoqiang Xu, Chengru Yang, Shaowu Bi, Xingming Jiang, Pengcheng Kang, Xiaoxue Xu, Xiangyu Zhong
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
circCPSK6
circular RNA
intrahepatic cholangiocarcinoma
NF‐κB
ubiquitination
Online Access:https://doi.org/10.1002/advs.202409173
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