Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage
Spontaneous spinal epidural hematoma (SSEH) is a rare neurosurgical emergency with paucity of data in understanding the pathogenesis. SSEH can be devastating to the patients as it causes permanent paraplegia if not treated in a timely manner. SSEH has been described in various coagulopathic disorder...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Spine Journal |
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| Online Access: | https://doi.org/10.4103/isj.isj_56_23 |
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| author | Monali M. Patil Pandurang Barve Trimurti D. Nadkarni Karansinh R. Parve Patil |
| author_facet | Monali M. Patil Pandurang Barve Trimurti D. Nadkarni Karansinh R. Parve Patil |
| author_sort | Monali M. Patil |
| collection | DOAJ |
| description | Spontaneous spinal epidural hematoma (SSEH) is a rare neurosurgical emergency with paucity of data in understanding the pathogenesis. SSEH can be devastating to the patients as it causes permanent paraplegia if not treated in a timely manner. SSEH has been described in various coagulopathic disorders but there have been no case reports of spontaneous epidural hematoma occurring in patients with beta thalassemia. We present a case report illustrating clinical features, magnetic resonance imaging findings, operative intervention, and outcome after surgery in a 17-year-old boy with beta thalassemia major, who presented to us with epidural hematoma in dorsolumbar spine, requiring emergency long segment laminotomy and evacuation of the epidural clot. The operative procedure resulted in a good outcome over a period of 6 months. We have proposed pathophysiology of formation of SSEH in beta thalassemia patients. The pathophysiology behind the hemorrhagic manifestation is not completely understood and requires further studies. Timely diagnosis is important to avoid life-threatening morbidity or mortality in such patients because surgical decompression with physiotherapy leads to good outcomes. |
| format | Article |
| id | doaj-art-ed9d5e93df1145908cfb96ac69ff7a9c |
| institution | OA Journals |
| issn | 2589-5079 2589-5087 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Spine Journal |
| spelling | doaj-art-ed9d5e93df1145908cfb96ac69ff7a9c2025-08-20T02:06:43ZengWolters Kluwer Medknow PublicationsIndian Spine Journal2589-50792589-50872025-01-0181818410.4103/isj.isj_56_23Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural HemorrhageMonali M. PatilPandurang BarveTrimurti D. NadkarniKaransinh R. Parve PatilSpontaneous spinal epidural hematoma (SSEH) is a rare neurosurgical emergency with paucity of data in understanding the pathogenesis. SSEH can be devastating to the patients as it causes permanent paraplegia if not treated in a timely manner. SSEH has been described in various coagulopathic disorders but there have been no case reports of spontaneous epidural hematoma occurring in patients with beta thalassemia. We present a case report illustrating clinical features, magnetic resonance imaging findings, operative intervention, and outcome after surgery in a 17-year-old boy with beta thalassemia major, who presented to us with epidural hematoma in dorsolumbar spine, requiring emergency long segment laminotomy and evacuation of the epidural clot. The operative procedure resulted in a good outcome over a period of 6 months. We have proposed pathophysiology of formation of SSEH in beta thalassemia patients. The pathophysiology behind the hemorrhagic manifestation is not completely understood and requires further studies. Timely diagnosis is important to avoid life-threatening morbidity or mortality in such patients because surgical decompression with physiotherapy leads to good outcomes.https://doi.org/10.4103/isj.isj_56_23beta thalassemiaepidural hematomaparaplegia |
| spellingShingle | Monali M. Patil Pandurang Barve Trimurti D. Nadkarni Karansinh R. Parve Patil Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage Indian Spine Journal beta thalassemia epidural hematoma paraplegia |
| title | Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage |
| title_full | Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage |
| title_fullStr | Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage |
| title_full_unstemmed | Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage |
| title_short | Beta Thalassemia Major as a Rare Cause of Spontaneous Spinal Epidural Hemorrhage |
| title_sort | beta thalassemia major as a rare cause of spontaneous spinal epidural hemorrhage |
| topic | beta thalassemia epidural hematoma paraplegia |
| url | https://doi.org/10.4103/isj.isj_56_23 |
| work_keys_str_mv | AT monalimpatil betathalassemiamajorasararecauseofspontaneousspinalepiduralhemorrhage AT pandurangbarve betathalassemiamajorasararecauseofspontaneousspinalepiduralhemorrhage AT trimurtidnadkarni betathalassemiamajorasararecauseofspontaneousspinalepiduralhemorrhage AT karansinhrparvepatil betathalassemiamajorasararecauseofspontaneousspinalepiduralhemorrhage |