Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention
Bacterial nanocellulose is a fascinating biopolymer with immense application potential, including as a wound dressing material. It is highly biocompatible and capable of keeping humidity needed for wound healing. However, it lacks specific affinity to pharmaceuticals to be delivered in a controlled...
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| Format: | Article |
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Elsevier
2025-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925000957 |
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| author | Troy C. Breijaert Marina Fontes Paula de Abreu Fernandes Hernane da Silva Barud Sidney J.L. Ribeiro Gulaim A. Seisenbaeva |
| author_facet | Troy C. Breijaert Marina Fontes Paula de Abreu Fernandes Hernane da Silva Barud Sidney J.L. Ribeiro Gulaim A. Seisenbaeva |
| author_sort | Troy C. Breijaert |
| collection | DOAJ |
| description | Bacterial nanocellulose is a fascinating biopolymer with immense application potential, including as a wound dressing material. It is highly biocompatible and capable of keeping humidity needed for wound healing. However, it lacks specific affinity to pharmaceuticals to be delivered in a controlled fashion in a topical application, urged by the necessity to decrease the release of medicines to the environment. Solving this problem requires tailoring of the material functionality by chemical modification. In this work, a two-step strategy applying first phosphorylation and then introduction of biocompatible mineral particles was applied. Surface modification of commercially available wound dressing material based on dried bacterial nanocellulose led to phosphate grafting of 1.5–1.8 mmol/g and then uniform coverage of individual fibers (colloidal TiO2) or formation of aggregated platelets (TiBALDH®) on the surface (with Ti:P element ratios 0.45–0.80). To the titania functionalized dressing the broad spectrum antibiotic Tetracycline was bound (41–45 mg g-1) with its release delayed over several hours / days (over 50 % in 120 h for both nanocarriers). Biological essays indicated excellent biocompatibility and improved cell adhesion, offering a path to accelerated wound closure, promising for diverse tissue engineering applications. This study demonstrated a strategy in approach to dressing materials with delayed drug release properties exploiting the affinity of pharmaceuticals to mineral nanoparticles. |
| format | Article |
| id | doaj-art-ed976b429fac416cb61a9a1ad1f7f694 |
| institution | DOAJ |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-ed976b429fac416cb61a9a1ad1f7f6942025-08-20T03:20:58ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010075610.1016/j.carpta.2025.100756Functionalization of bacterial nanocellulose-based wound dressing for increased drug retentionTroy C. Breijaert0Marina Fontes1Paula de Abreu Fernandes2Hernane da Silva Barud3Sidney J.L. Ribeiro4Gulaim A. Seisenbaeva5Department of Molecular Science, Swedish University of Agricultural Science, Uppsala, 756 51 Ultuna, SwedenDepartment of Chemistry, Federal University of São Carlos (UFSCar), São Carlos, 13565-905, SP, BrazilDepartment of Biotechnology, University of Araraquara (UNIARA), 14801340, Araraquara, SP, BrazilDepartment of Biotechnology, University of Araraquara (UNIARA), 14801340, Araraquara, SP, Brazil; Institute of Chemistry, São Paulo State University – UNESP, Araraquara, SP, 14800-900 BrazilInstitute of Chemistry, São Paulo State University – UNESP, Araraquara, SP, 14800-900 BrazilDepartment of Molecular Science, Swedish University of Agricultural Science, Uppsala, 756 51 Ultuna, Sweden; Corresponding author.Bacterial nanocellulose is a fascinating biopolymer with immense application potential, including as a wound dressing material. It is highly biocompatible and capable of keeping humidity needed for wound healing. However, it lacks specific affinity to pharmaceuticals to be delivered in a controlled fashion in a topical application, urged by the necessity to decrease the release of medicines to the environment. Solving this problem requires tailoring of the material functionality by chemical modification. In this work, a two-step strategy applying first phosphorylation and then introduction of biocompatible mineral particles was applied. Surface modification of commercially available wound dressing material based on dried bacterial nanocellulose led to phosphate grafting of 1.5–1.8 mmol/g and then uniform coverage of individual fibers (colloidal TiO2) or formation of aggregated platelets (TiBALDH®) on the surface (with Ti:P element ratios 0.45–0.80). To the titania functionalized dressing the broad spectrum antibiotic Tetracycline was bound (41–45 mg g-1) with its release delayed over several hours / days (over 50 % in 120 h for both nanocarriers). Biological essays indicated excellent biocompatibility and improved cell adhesion, offering a path to accelerated wound closure, promising for diverse tissue engineering applications. This study demonstrated a strategy in approach to dressing materials with delayed drug release properties exploiting the affinity of pharmaceuticals to mineral nanoparticles.http://www.sciencedirect.com/science/article/pii/S2666893925000957Bacterial nanocelluloseWound dressingPhosphorylationDrug deliveryTitania |
| spellingShingle | Troy C. Breijaert Marina Fontes Paula de Abreu Fernandes Hernane da Silva Barud Sidney J.L. Ribeiro Gulaim A. Seisenbaeva Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention Carbohydrate Polymer Technologies and Applications Bacterial nanocellulose Wound dressing Phosphorylation Drug delivery Titania |
| title | Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention |
| title_full | Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention |
| title_fullStr | Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention |
| title_full_unstemmed | Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention |
| title_short | Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention |
| title_sort | functionalization of bacterial nanocellulose based wound dressing for increased drug retention |
| topic | Bacterial nanocellulose Wound dressing Phosphorylation Drug delivery Titania |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925000957 |
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