Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study
Purpose: Cardiovascular disease (CVD) is more prevalent in men than women, but the mechanisms responsible for this are not fully understood. We aimed to evaluate differences in trimethylamine (TMA), a microbial metabolite and its oxidized form, trimethylamine N-oxide (TMAO), which is thought to pr...
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Korean Society for Sexual Medicine and Andrology
2025-01-01
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| Series: | The World Journal of Men's Health |
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| author | Helena Garcia-Fernandez Juan F. Alcala-Diaz Gracia M. Quintana-Navarro Javier Lopez-Moreno Diego Luque-Cordoba Eugenia Ruiz-Diaz Narvaez Antonio P. Arenas-de Larriva Francisco M. Gutierrez-Mariscal Jose D. Torres-Peña Diego Rodriguez-Cano Raul M. Luque Feliciano Priego-Capote Jose Lopez-Miranda Antonio Camargo |
| author_facet | Helena Garcia-Fernandez Juan F. Alcala-Diaz Gracia M. Quintana-Navarro Javier Lopez-Moreno Diego Luque-Cordoba Eugenia Ruiz-Diaz Narvaez Antonio P. Arenas-de Larriva Francisco M. Gutierrez-Mariscal Jose D. Torres-Peña Diego Rodriguez-Cano Raul M. Luque Feliciano Priego-Capote Jose Lopez-Miranda Antonio Camargo |
| author_sort | Helena Garcia-Fernandez |
| collection | DOAJ |
| description | Purpose: Cardiovascular disease (CVD) is more prevalent in men than women, but the mechanisms responsible for this are
not fully understood. We aimed to evaluate differences in trimethylamine (TMA), a microbial metabolite and its oxidized
form, trimethylamine N-oxide (TMAO), which is thought to promote atherosclerosis, between men and women with coronary
heart disease (CHD), using as a reference a non-CVD population.
Materials and Methods: This study was carried out within the framework of the CORDIOPREV study (NCT00924937; June
19, 2009), a clinical trial which included 827 men and 175 women with CHD, with a non-CVD population of 375 individuals
(270 men and 105 women) as a reference group. Plasma TMA and TMAO were measured by HPLC-MS/MS. The carotid
study was ultrasonically assessed bilaterally by the quantification of intima-media thickness of both common carotid arteries
(IMT-CC).
Results: We found higher TMAO levels and TMAO/TMA ratio in CHD men than CHD women (p=0.034 and p=0.026, respectively).
No TMA sex differences were found in CHD patients. The TMA and TMAO levels and TMAO/TMA ratio were
lower, and no differences between sexes were found in the non-CVD population. TMAO levels in CHD patients were consistent
with higher IMT-CC and more carotid plaques (p=0.032 and p=0.037, respectively) and lower cholesterol efflux in CHD
men than CHD women (p<0.001). Conclusions: Our results suggest that CHD men have augmented TMAO levels compared with CHD women, presumably as
a consequence of higher rate of TMA to TMAO oxidation, which could be associated with CVD, as these sex differences are
not observed in a non-CVD population. |
| format | Article |
| id | doaj-art-ed93dd93a8374662bfcd0c742309b4c5 |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-ed93dd93a8374662bfcd0c742309b4c52025-01-03T06:56:34ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-01-0143124925810.5534/wjmh.230366Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV StudyHelena Garcia-Fernandez0https://orcid.org/0000-0002-7277-852XJuan F. Alcala-Diaz1https://orcid.org/0000-0002-4572-3611Gracia M. Quintana-Navarro2https://orcid.org/0000-0003-4413-4062Javier Lopez-Moreno3https://orcid.org/0000-0002-4222-1392Diego Luque-Cordoba4https://orcid.org/0000-0002-6694-1829Eugenia Ruiz-Diaz Narvaez5https://orcid.org/0000-0001-8612-4458Antonio P. Arenas-de Larriva6https://orcid.org/0000-0001-8897-5176Francisco M. Gutierrez-Mariscal7https://orcid.org/0000-0003-3353-2188Jose D. Torres-Peña8https://orcid.org/0000-0003-1366-5549Diego Rodriguez-Cano9https://orcid.org/0000-0002-5917-1088Raul M. Luque10https://orcid.org/0000-0002-7585-1913Feliciano Priego-Capote11https://orcid.org/0000-0003-0697-719XJose Lopez-Miranda12https://orcid.org/0000-0002-8844-0718Antonio Camargo13https://orcid.org/0000-0002-0415-4184Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainMaimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, SpainDepartment of Clinical Nutrition and Diet Therapy, Clinics Hospital, Faculty of Medical Sciences, National University of Asuncion, San Lorenzo, ParaguayLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainClinical Analysis Service, Reina Sofia University Hospital, Cordoba, SpainMaimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, SpainMaimonides Institute for Biomedical Research in Cordoba (IMIBIC), Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainLipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofía University Hospital, Cordoba, SpainPurpose: Cardiovascular disease (CVD) is more prevalent in men than women, but the mechanisms responsible for this are not fully understood. We aimed to evaluate differences in trimethylamine (TMA), a microbial metabolite and its oxidized form, trimethylamine N-oxide (TMAO), which is thought to promote atherosclerosis, between men and women with coronary heart disease (CHD), using as a reference a non-CVD population. Materials and Methods: This study was carried out within the framework of the CORDIOPREV study (NCT00924937; June 19, 2009), a clinical trial which included 827 men and 175 women with CHD, with a non-CVD population of 375 individuals (270 men and 105 women) as a reference group. Plasma TMA and TMAO were measured by HPLC-MS/MS. The carotid study was ultrasonically assessed bilaterally by the quantification of intima-media thickness of both common carotid arteries (IMT-CC). Results: We found higher TMAO levels and TMAO/TMA ratio in CHD men than CHD women (p=0.034 and p=0.026, respectively). No TMA sex differences were found in CHD patients. The TMA and TMAO levels and TMAO/TMA ratio were lower, and no differences between sexes were found in the non-CVD population. TMAO levels in CHD patients were consistent with higher IMT-CC and more carotid plaques (p=0.032 and p=0.037, respectively) and lower cholesterol efflux in CHD men than CHD women (p<0.001). Conclusions: Our results suggest that CHD men have augmented TMAO levels compared with CHD women, presumably as a consequence of higher rate of TMA to TMAO oxidation, which could be associated with CVD, as these sex differences are not observed in a non-CVD population.atherosclerosiscardiovascular diseasesdysbiosisgastrointestinal microbiomesex characteristics |
| spellingShingle | Helena Garcia-Fernandez Juan F. Alcala-Diaz Gracia M. Quintana-Navarro Javier Lopez-Moreno Diego Luque-Cordoba Eugenia Ruiz-Diaz Narvaez Antonio P. Arenas-de Larriva Francisco M. Gutierrez-Mariscal Jose D. Torres-Peña Diego Rodriguez-Cano Raul M. Luque Feliciano Priego-Capote Jose Lopez-Miranda Antonio Camargo Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study The World Journal of Men's Health atherosclerosis cardiovascular diseases dysbiosis gastrointestinal microbiome sex characteristics |
| title | Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study |
| title_full | Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study |
| title_fullStr | Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study |
| title_full_unstemmed | Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study |
| title_short | Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study |
| title_sort | trimethylamine oxidation into the proatherogenic trimethylamine n oxide is higher in coronary heart disease men from the cordioprev study |
| topic | atherosclerosis cardiovascular diseases dysbiosis gastrointestinal microbiome sex characteristics |
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