Impact of Fixed Orthodontic Appliances on Blood Count and High-Sensitivity C-Reactive Protein Levels
Background: Fixed orthodontic appliances are widely used in dental practice to correct malocclusions and improving oral health. However, their impact on systemic inflammation and hematological parameters remains under-explored. Materials and Methods: A cohort of 60 patients, aged 12 –30 years, under...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_882_24 |
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| Summary: | Background:
Fixed orthodontic appliances are widely used in dental practice to correct malocclusions and improving oral health. However, their impact on systemic inflammation and hematological parameters remains under-explored.
Materials and Methods:
A cohort of 60 patients, aged 12 –30 years, undergoing fixed orthodontic treatment, were enrolled in the study. Blood samples were collected at baseline, 1 month, and 6 months post-appliance placement. Hematological parameters, including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin levels, and hs-CRP levels, were measured using standard laboratory techniques. A statistical analysis was performed to determine significant changes over time.
Results:
At 1-month post-appliance placement, a significant increase in WBC count (mean increase of 12%) and hs-CRP levels (mean increase of 18%) was observed compared to baseline (P < 0.05). RBC count and hemoglobin levels remained relatively unchanged. By 6 months, WBC count and hs-CRP levels showed a decreasing trend, approaching baseline values, though hs-CRP levels remained slightly elevated (mean increase of 5% from baseline, P > 0.05).
Conclusion:
The use of fixed orthodontic appliances induces a transient inflammatory response, as evidenced by elevated WBC count and hs-CRP levels within the first month of treatment. |
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| ISSN: | 0976-4879 0975-7406 |