Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms

Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms

Abstract Background Previous research on the lower gastrointestinal tract has proved that microbial dysbiosis can lead to intestinal barrier dysfunction and enhanced visceral sensitivity, thus triggering bowel symptoms. Whether esophageal microbial dysbiosis also contributes to the development of ga...

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Bibliographic Details
Main Authors: Songfeng Chen, Dianxuan Jiang, Qianjun Zhuang, Xun Hou, Xingyu Jia, Jing Chen, Huiting Lin, Mengyu Zhang, Niandi Tan, Yinglian Xiao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Esophageal microbiota
Lipopolysaccharide
Interleukin-6
Esophageal barrier integrity
Online Access:https://doi.org/10.1186/s12967-024-05878-1
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