The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation
Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions o...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/202513 |
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| author | Kuo-Sheng Wu Yi-Jen Hung Chien-Hsing Lee Fone-Ching Hsiao Po-Shiuan Hsieh |
| author_facet | Kuo-Sheng Wu Yi-Jen Hung Chien-Hsing Lee Fone-Ching Hsiao Po-Shiuan Hsieh |
| author_sort | Kuo-Sheng Wu |
| collection | DOAJ |
| description | Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type. While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity. Accordingly, the participation of GAS6 in the progression of obesity remains controversial. In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders. In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications. |
| format | Article |
| id | doaj-art-ed8f02eaa3c94c9dba9566c6f399c7b7 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ed8f02eaa3c94c9dba9566c6f399c7b72025-08-20T03:21:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/202513202513The Involvement of GAS6 Signaling in the Development of Obesity and Associated InflammationKuo-Sheng Wu0Yi-Jen Hung1Chien-Hsing Lee2Fone-Ching Hsiao3Po-Shiuan Hsieh4Department of Physiology and Biophysics, National Defense Medical Center, Taipei 114, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDepartment of Physiology and Biophysics, National Defense Medical Center, Taipei 114, TaiwanGrowth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type. While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity. Accordingly, the participation of GAS6 in the progression of obesity remains controversial. In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders. In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications.http://dx.doi.org/10.1155/2015/202513 |
| spellingShingle | Kuo-Sheng Wu Yi-Jen Hung Chien-Hsing Lee Fone-Ching Hsiao Po-Shiuan Hsieh The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation International Journal of Endocrinology |
| title | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
| title_full | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
| title_fullStr | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
| title_full_unstemmed | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
| title_short | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
| title_sort | involvement of gas6 signaling in the development of obesity and associated inflammation |
| url | http://dx.doi.org/10.1155/2015/202513 |
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