Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases
We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recur...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/8353745 |
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| author | Aristeidis Hristos Zibis Apostolos Haralampos Fyllos Sophia Havaki Sotirios Sotiriou Georgios Kotakidis Dimitrios Leonidas Arvanitis |
| author_facet | Aristeidis Hristos Zibis Apostolos Haralampos Fyllos Sophia Havaki Sotirios Sotiriou Georgios Kotakidis Dimitrios Leonidas Arvanitis |
| author_sort | Aristeidis Hristos Zibis |
| collection | DOAJ |
| description | We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ipsilateral inguinal lymph nodes were noticed. The final pathological examination showed multiple separated malignant foci, some with overlying pagetoid phenomenon and inguinal lymph node metastases. Immunohistochemistry showed positivity for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factor Receptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high score cases exhibit a worse prognosis. |
| format | Article |
| id | doaj-art-ed8361a9243e49c48a9182f68c8d1e3b |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-ed8361a9243e49c48a9182f68c8d1e3b2025-02-03T01:11:08ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/83537458353745Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node MetastasesAristeidis Hristos Zibis0Apostolos Haralampos Fyllos1Sophia Havaki2Sotirios Sotiriou3Georgios Kotakidis4Dimitrios Leonidas Arvanitis5Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, GreeceDepartment of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, GreeceDepartment of Histology and Embryology, National and Kapodistrian University of Athens, Medical School, Athens, GreeceDepartment of Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, GreeceDepartment of Urology, General Hospital of Florina, Florina, GreeceDepartment of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, GreeceWe report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ipsilateral inguinal lymph nodes were noticed. The final pathological examination showed multiple separated malignant foci, some with overlying pagetoid phenomenon and inguinal lymph node metastases. Immunohistochemistry showed positivity for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factor Receptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high score cases exhibit a worse prognosis.http://dx.doi.org/10.1155/2016/8353745 |
| spellingShingle | Aristeidis Hristos Zibis Apostolos Haralampos Fyllos Sophia Havaki Sotirios Sotiriou Georgios Kotakidis Dimitrios Leonidas Arvanitis Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases Case Reports in Oncological Medicine |
| title | Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases |
| title_full | Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases |
| title_fullStr | Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases |
| title_full_unstemmed | Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases |
| title_short | Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases |
| title_sort | scrotal apocrine adenocarcinoma with pagetoid phenomenon and inguinal lymph node metastases |
| url | http://dx.doi.org/10.1155/2016/8353745 |
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