METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS
As new effective biological agents (BAs) are being widely introduced, in the past decade there have been serious changes in the rheumatoid arthritis (RA) strategy: its basis was the treat-to-target concept. It is emphasized that the basic strategy component is active early aggressive therapy with me...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2015-10-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2140 |
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| author | E. L. Nasonov |
| author_facet | E. L. Nasonov |
| author_sort | E. L. Nasonov |
| collection | DOAJ |
| description | As new effective biological agents (BAs) are being widely introduced, in the past decade there have been serious changes in the rheumatoid arthritis (RA) strategy: its basis was the treat-to-target concept. It is emphasized that the basic strategy component is active early aggressive therapy with methotrexate (MT) and, if MT monotherapy is inade- quately ineffective, combined therapy with MT and standard disease-modifying antirheumatic drugs or MT and BAs. Although oral MT is more frequently prescribed in randomized placebo-controlled trials (RPCTs) and in clinical practice, there is now a tendency towards the wider use of its subcutaneous formulation. Novel evidence from funda- mental studies dealing with the deciphering of the mechanism of MT action and the materials of numerous RPCTs, observational studies, and national registries substantiate the unique place of MT in the treatment of RA, its complica- tions, and comorbidities. The purpose of the review is to analyze new data on the mechanism of action of MT and its clinical efficacy and safety in rheumatology. |
| format | Article |
| id | doaj-art-ed8348c1df5c48c0bea36a3a372acd2d |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-ed8348c1df5c48c0bea36a3a372acd2d2025-08-20T03:21:50ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922015-10-01535s647610.14412/1995-4484-2015-64-762023METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEASE. L. Nasonov0ФГБНУ Научно-иссле- довательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34АAs new effective biological agents (BAs) are being widely introduced, in the past decade there have been serious changes in the rheumatoid arthritis (RA) strategy: its basis was the treat-to-target concept. It is emphasized that the basic strategy component is active early aggressive therapy with methotrexate (MT) and, if MT monotherapy is inade- quately ineffective, combined therapy with MT and standard disease-modifying antirheumatic drugs or MT and BAs. Although oral MT is more frequently prescribed in randomized placebo-controlled trials (RPCTs) and in clinical practice, there is now a tendency towards the wider use of its subcutaneous formulation. Novel evidence from funda- mental studies dealing with the deciphering of the mechanism of MT action and the materials of numerous RPCTs, observational studies, and national registries substantiate the unique place of MT in the treatment of RA, its complica- tions, and comorbidities. The purpose of the review is to analyze new data on the mechanism of action of MT and its clinical efficacy and safety in rheumatology.https://rsp.mediar-press.net/rsp/article/view/2140rheumatoid arthritismethotrexatebiological agents |
| spellingShingle | E. L. Nasonov METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS Научно-практическая ревматология rheumatoid arthritis methotrexate biological agents |
| title | METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS |
| title_full | METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS |
| title_fullStr | METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS |
| title_full_unstemmed | METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS |
| title_short | METHOTREXATE IN RHEUMATOID ARTHRITIS – 2015: NEW FACTS AND IDEAS |
| title_sort | methotrexate in rheumatoid arthritis 2015 new facts and ideas |
| topic | rheumatoid arthritis methotrexate biological agents |
| url | https://rsp.mediar-press.net/rsp/article/view/2140 |
| work_keys_str_mv | AT elnasonov methotrexateinrheumatoidarthritis2015newfactsandideas |