Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C
Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotect...
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| Format: | Article |
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2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/6618273 |
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| author | Eimad Dine Tariq Bouhlali Mgal Derouich Abdelbassat Hmidani Bouchra Bourkhis Tarik Khouya Younes Filali-Zegzouti Chakib Alem |
| author_facet | Eimad Dine Tariq Bouhlali Mgal Derouich Abdelbassat Hmidani Bouchra Bourkhis Tarik Khouya Younes Filali-Zegzouti Chakib Alem |
| author_sort | Eimad Dine Tariq Bouhlali |
| collection | DOAJ |
| description | Phoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as Jihl and Majhoul, aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. The polyphenol profile was built by means of an HPLC analysis. Hepatic damage was provoked by exposing rats to PCM at a dose of 1.5 g/kg once a week. Besides PCM, Jihl and Majhoul date seed extracts (200 and 400 mg/kg) were administered orally in a day-to-day routine. Our findings showed that among the examined polyphenol compounds, p-coumaric acid, quercetin, caffeic acid, and rutin were the most abundant phytochemicals. Date pits significantly (p<0.001) stabilized the PCM-driven alterations in liver function parameters (AST, ALT, ALP, LDH, total protein, direct bilirubin, and total bilirubin). Moreover, Phoenix dactylifera pits enhanced considerably (p<0.001) the activities of antioxidant enzymes (SOD, CAT, and GPx) as well as the level of reduced glutathione (GSH). The established hepatoprotective effect may be due to the date seeds antioxidant effect and their ability to trap free radicals. The main outcomes of the present study could validate the traditional use of these date seeds to manage various health conditions. |
| format | Article |
| id | doaj-art-ed8306e989cd44ebb872de1f7df25939 |
| institution | DOAJ |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ed8306e989cd44ebb872de1f7df259392025-08-20T03:21:11ZengWileyThe Scientific World Journal2356-61401537-744X2021-01-01202110.1155/2021/66182736618273Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin CEimad Dine Tariq Bouhlali0Mgal Derouich1Abdelbassat Hmidani2Bouchra Bourkhis3Tarik Khouya4Younes Filali-Zegzouti5Chakib Alem6National Institute of Agronomic Research, Regional Center of Errachidia, Errachidia, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, MoroccoFaculty of Medicine and Pharmacy of Fes, Fes, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, MoroccoBiology, Environment and Health Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, MoroccoPhoenix dactylifera L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as Jihl and Majhoul, aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. The polyphenol profile was built by means of an HPLC analysis. Hepatic damage was provoked by exposing rats to PCM at a dose of 1.5 g/kg once a week. Besides PCM, Jihl and Majhoul date seed extracts (200 and 400 mg/kg) were administered orally in a day-to-day routine. Our findings showed that among the examined polyphenol compounds, p-coumaric acid, quercetin, caffeic acid, and rutin were the most abundant phytochemicals. Date pits significantly (p<0.001) stabilized the PCM-driven alterations in liver function parameters (AST, ALT, ALP, LDH, total protein, direct bilirubin, and total bilirubin). Moreover, Phoenix dactylifera pits enhanced considerably (p<0.001) the activities of antioxidant enzymes (SOD, CAT, and GPx) as well as the level of reduced glutathione (GSH). The established hepatoprotective effect may be due to the date seeds antioxidant effect and their ability to trap free radicals. The main outcomes of the present study could validate the traditional use of these date seeds to manage various health conditions.http://dx.doi.org/10.1155/2021/6618273 |
| spellingShingle | Eimad Dine Tariq Bouhlali Mgal Derouich Abdelbassat Hmidani Bouchra Bourkhis Tarik Khouya Younes Filali-Zegzouti Chakib Alem Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C The Scientific World Journal |
| title | Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C |
| title_full | Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C |
| title_fullStr | Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C |
| title_full_unstemmed | Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C |
| title_short | Protective Effect of Phoenix dactylifera L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C |
| title_sort | protective effect of phoenix dactylifera l seeds against paracetamol induced hepatotoxicity in rats a comparison with vitamin c |
| url | http://dx.doi.org/10.1155/2021/6618273 |
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