A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran
Background & Aims: Corneal transplantation is considered the most transplanted solid tissue in humans. The purpose of the present investigation was to recognize the main indications and risk factors for allograft rejection. Materials & Methods: The medical files of all subjects who underwent...
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Urmia University of Medical Sciences
2024-11-01
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| Series: | Health Science Monitor |
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| Online Access: | http://hsm.umsu.ac.ir/article-1-185-en.pdf |
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| author | Naser Samadi Aidenloo Qader Motarjemizadeh Ayyub Shamsi |
| author_facet | Naser Samadi Aidenloo Qader Motarjemizadeh Ayyub Shamsi |
| author_sort | Naser Samadi Aidenloo |
| collection | DOAJ |
| description | Background & Aims: Corneal transplantation is considered the most transplanted solid tissue in humans. The purpose of the present investigation was to recognize the main indications and risk factors for allograft rejection.
Materials & Methods: The medical files of all subjects who underwent penetrating keratoplasty at a major referral center in Northwest Iran (Urmia Imam Hospital) were retrospectively reviewed, regardless of the indication for transplantation, over a 13-year period, from 20 March 2002 to 19 March 2015.
Results: In total, 327 cases of corneal transplantation were examined (mean age: 53.48 ± 22.44 years). Of these, 170 patients (52%) were male. Out of 327 individuals, 42 cases (12.8%) experienced graft rejection. Nearly three-quarters of rejected transplants (N = 31, 73.8%) occurred in patients ≥ 40 years (p = 0.381). No significant association was detected between graft rejection and gender (p = 0.136). The most frequent indications for corneal transplantation in cases with rejection were leukoma (N = 13, 31.0%), trauma (N = 12, 28.6%), and pseudophakic bullous keratopathy (PBK) (N = 9, 21.4%). The most prevalent causes of graft rejection included delayed follow-up (N = 17, 40.4%), recurrence of corneal dystrophies (N = 9, 21.4%), and graft failure (N = 9, 21.4%). Only 3 out of 17 patients (17.6%) with delayed follow-up achieved graft restoration.
Conclusion: This study suggests a link between delayed follow-up and graft rejection. Prompt intervention improves the chances of regaining graft clarity, and patients must be well informed about the importance of follow-up visits. |
| format | Article |
| id | doaj-art-ed81c050b8c44ccc85f76dfdb8788a11 |
| institution | OA Journals |
| issn | 2980-8723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Urmia University of Medical Sciences |
| record_format | Article |
| series | Health Science Monitor |
| spelling | doaj-art-ed81c050b8c44ccc85f76dfdb8788a112025-08-20T02:07:32ZengUrmia University of Medical SciencesHealth Science Monitor2980-87232024-11-0134298305A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest IranNaser Samadi Aidenloo0Qader Motarjemizadeh1Ayyub Shamsi2 Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Background & Aims: Corneal transplantation is considered the most transplanted solid tissue in humans. The purpose of the present investigation was to recognize the main indications and risk factors for allograft rejection. Materials & Methods: The medical files of all subjects who underwent penetrating keratoplasty at a major referral center in Northwest Iran (Urmia Imam Hospital) were retrospectively reviewed, regardless of the indication for transplantation, over a 13-year period, from 20 March 2002 to 19 March 2015. Results: In total, 327 cases of corneal transplantation were examined (mean age: 53.48 ± 22.44 years). Of these, 170 patients (52%) were male. Out of 327 individuals, 42 cases (12.8%) experienced graft rejection. Nearly three-quarters of rejected transplants (N = 31, 73.8%) occurred in patients ≥ 40 years (p = 0.381). No significant association was detected between graft rejection and gender (p = 0.136). The most frequent indications for corneal transplantation in cases with rejection were leukoma (N = 13, 31.0%), trauma (N = 12, 28.6%), and pseudophakic bullous keratopathy (PBK) (N = 9, 21.4%). The most prevalent causes of graft rejection included delayed follow-up (N = 17, 40.4%), recurrence of corneal dystrophies (N = 9, 21.4%), and graft failure (N = 9, 21.4%). Only 3 out of 17 patients (17.6%) with delayed follow-up achieved graft restoration. Conclusion: This study suggests a link between delayed follow-up and graft rejection. Prompt intervention improves the chances of regaining graft clarity, and patients must be well informed about the importance of follow-up visits.http://hsm.umsu.ac.ir/article-1-185-en.pdfbullous keratopathycorneal transplantationgraft rejectiontrauma |
| spellingShingle | Naser Samadi Aidenloo Qader Motarjemizadeh Ayyub Shamsi A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran Health Science Monitor bullous keratopathy corneal transplantation graft rejection trauma |
| title | A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran |
| title_full | A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran |
| title_fullStr | A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran |
| title_full_unstemmed | A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran |
| title_short | A 13-year descriptive study of corneal transplants at a tertiary, teaching hospital in northwest Iran |
| title_sort | 13 year descriptive study of corneal transplants at a tertiary teaching hospital in northwest iran |
| topic | bullous keratopathy corneal transplantation graft rejection trauma |
| url | http://hsm.umsu.ac.ir/article-1-185-en.pdf |
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