Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review)
Literature review provides the analysis of treatment results of implementing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with cytogenetically unfavorable acute myeloid and lymphoblastic leukemias including monosomal, complex, and hyperdiploid karyotypes, t(3;3)/inv(3),...
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| Format: | Article |
| Language: | Russian |
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Practical Medicine Publishing House
2019-03-01
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| Series: | Клиническая онкогематология |
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http://bloodjournal.ru/wp-content/uploads/2019/03/1-6.pdf
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| _version_ | 1849690890700849152 |
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| author | NN Mamaev TL Gindina BV Afanas’ev |
| author_facet | NN Mamaev TL Gindina BV Afanas’ev |
| author_sort | NN Mamaev |
| collection | DOAJ |
| description | Literature review provides the analysis of treatment results of implementing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with cytogenetically unfavorable acute myeloid and lymphoblastic leukemias including monosomal, complex, and hyperdiploid karyotypes, t(3;3)/inv(3), t(v;11)(v;q23), t(4;11)(q21;q23), t(9;22)(q34;q11) translocations, 17p abnormalities, and some other disorders. The major disadvantage of allo-HSCT seems to be linked to a strong chromosome-damaging effect of cytostatic drugs used in conditioning regimens which in turn is associated with additional chromosome abnormalities occurring in tumors, increasing genomic instability, and tumor progression. On the other hand, one of the advantages of allo-HSCT can consist in its specific “graft versus leukemia” (GVL) effect whose degree has not yet been adequately studied. To minimize the risks of allo-HSCT in above mentioned patients it appears appropriate to apply new treatment approaches based on de-escalation of chromosome- and whole-genome-damaging effects and also to introduce recent methods of active stimulation and qualitative assessment of GVL effect into clinical practice. |
| format | Article |
| id | doaj-art-ed7e9f56a0294ebba1d1135e2424c45a |
| institution | DOAJ |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-ed7e9f56a0294ebba1d1135e2424c45a2025-08-20T03:21:11ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392019-03-0112211111910.21320/2500-2139-2019-12-2-111-11919976933Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review)NN Mamaev0TL Gindina1BV Afanas’ev2 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 RM Gorbacheva Scientific Research Institute of Pediatric Oncology, Hematology and Transplantation; IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022 Literature review provides the analysis of treatment results of implementing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with cytogenetically unfavorable acute myeloid and lymphoblastic leukemias including monosomal, complex, and hyperdiploid karyotypes, t(3;3)/inv(3), t(v;11)(v;q23), t(4;11)(q21;q23), t(9;22)(q34;q11) translocations, 17p abnormalities, and some other disorders. The major disadvantage of allo-HSCT seems to be linked to a strong chromosome-damaging effect of cytostatic drugs used in conditioning regimens which in turn is associated with additional chromosome abnormalities occurring in tumors, increasing genomic instability, and tumor progression. On the other hand, one of the advantages of allo-HSCT can consist in its specific “graft versus leukemia” (GVL) effect whose degree has not yet been adequately studied. To minimize the risks of allo-HSCT in above mentioned patients it appears appropriate to apply new treatment approaches based on de-escalation of chromosome- and whole-genome-damaging effects and also to introduce recent methods of active stimulation and qualitative assessment of GVL effect into clinical practice. http://bloodjournal.ru/wp-content/uploads/2019/03/1-6.pdf acute leukemiascytogenetically unfavorable variantsallo-hsctoutcomesadditional chromosome abnormalities"graft versus leukemia" effect |
| spellingShingle | NN Mamaev TL Gindina BV Afanas’ev Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) Клиническая онкогематология acute leukemias cytogenetically unfavorable variants allo-hsct outcomes additional chromosome abnormalities "graft versus leukemia" effect |
| title | Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) |
| title_full | Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) |
| title_fullStr | Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) |
| title_full_unstemmed | Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) |
| title_short | Achievements and Challenges in Allogeneic Hematopoietic Stem Cell Transplantation in Cytogenetically Unfavorable Acute Leukemias (Literature Review) |
| title_sort | achievements and challenges in allogeneic hematopoietic stem cell transplantation in cytogenetically unfavorable acute leukemias literature review |
| topic | acute leukemias cytogenetically unfavorable variants allo-hsct outcomes additional chromosome abnormalities "graft versus leukemia" effect |
| url |
http://bloodjournal.ru/wp-content/uploads/2019/03/1-6.pdf
|
| work_keys_str_mv | AT nnmamaev achievementsandchallengesinallogeneichematopoieticstemcelltransplantationincytogeneticallyunfavorableacuteleukemiasliteraturereview AT tlgindina achievementsandchallengesinallogeneichematopoieticstemcelltransplantationincytogeneticallyunfavorableacuteleukemiasliteraturereview AT bvafanasev achievementsandchallengesinallogeneichematopoieticstemcelltransplantationincytogeneticallyunfavorableacuteleukemiasliteraturereview |