Signaling pathways in the regulation of cancer stem cells and associated targeted therapy
Abstract Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor phenotypes, including recurrence, metastasis,...
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Wiley
2022-12-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.176 |
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| author | Wang Manni Wu Min |
| author_facet | Wang Manni Wu Min |
| author_sort | Wang Manni |
| collection | DOAJ |
| description | Abstract Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor phenotypes, including recurrence, metastasis, and treatment failure. A number of signaling pathways are involved in the maintenance of stem cell properties and survival of CSCs, including well‐established intrinsic pathways, such as the Notch, Wnt, and Hedgehog signaling, and extrinsic pathways, such as the vascular microenvironment and tumor‐associated immune cells. There is also intricate crosstalk between these signal cascades and other oncogenic pathways. Thus, targeting pathway molecules that regulate CSCs provides a new option for the treatment of therapy‐resistant or ‐refractory tumors. These treatments include small molecule inhibitors, monoclonal antibodies that target key signaling in CSCs, as well as CSC‐directed immunotherapies that harness the immune systems to target CSCs. This review aims to provide an overview of the regulating networks and their immune interactions involved in CSC development. We also address the update on the development of CSC‐directed therapeutics, with a special focus on those with application approval or under clinical evaluation. |
| format | Article |
| id | doaj-art-ed7a5cc2da4147f1bd9db67f00caacef |
| institution | DOAJ |
| issn | 2688-2663 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-ed7a5cc2da4147f1bd9db67f00caacef2025-08-20T02:56:45ZengWileyMedComm2688-26632022-12-0134n/an/a10.1002/mco2.176Signaling pathways in the regulation of cancer stem cells and associated targeted therapyWang Manni0Wu Min1Department of Biotherapy, Cancer Center, West China Hospital Sichuan University Chengdu P. R. ChinaDepartment of Biomedical Sciences, School of Medicine and Health Sciences University of North Dakota Grand Forks North Dakota USAAbstract Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into bulks, which are believed as a major cause of progressive tumor phenotypes, including recurrence, metastasis, and treatment failure. A number of signaling pathways are involved in the maintenance of stem cell properties and survival of CSCs, including well‐established intrinsic pathways, such as the Notch, Wnt, and Hedgehog signaling, and extrinsic pathways, such as the vascular microenvironment and tumor‐associated immune cells. There is also intricate crosstalk between these signal cascades and other oncogenic pathways. Thus, targeting pathway molecules that regulate CSCs provides a new option for the treatment of therapy‐resistant or ‐refractory tumors. These treatments include small molecule inhibitors, monoclonal antibodies that target key signaling in CSCs, as well as CSC‐directed immunotherapies that harness the immune systems to target CSCs. This review aims to provide an overview of the regulating networks and their immune interactions involved in CSC development. We also address the update on the development of CSC‐directed therapeutics, with a special focus on those with application approval or under clinical evaluation.https://doi.org/10.1002/mco2.176cancer stem cellsCAR‐T therapiesinhibitorssignal pathway |
| spellingShingle | Wang Manni Wu Min Signaling pathways in the regulation of cancer stem cells and associated targeted therapy MedComm cancer stem cells CAR‐T therapies inhibitors signal pathway |
| title | Signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| title_full | Signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| title_fullStr | Signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| title_full_unstemmed | Signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| title_short | Signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| title_sort | signaling pathways in the regulation of cancer stem cells and associated targeted therapy |
| topic | cancer stem cells CAR‐T therapies inhibitors signal pathway |
| url | https://doi.org/10.1002/mco2.176 |
| work_keys_str_mv | AT wangmanni signalingpathwaysintheregulationofcancerstemcellsandassociatedtargetedtherapy AT wumin signalingpathwaysintheregulationofcancerstemcellsandassociatedtargetedtherapy |