A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia
Background and Aim: Dengue fever, primarily transmitted by Aedes aegypti, remains a critical public health challenge in Indonesia, with periodic outbreaks exacerbated by widespread insecticide resistance. Resistance to organophosphates and pyrethroids limits vector control efforts, necessitating upd...
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Veterinary World
2025-03-01
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| Series: | Veterinary World |
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| Online Access: | https://www.veterinaryworld.org/Vol.18/March-2025/13.pdf |
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| author | Muhammad Rasyid Ridha Ririh Yudhastuti Hari Basuki Notobroto Muhammad Choirul Hidajat Khuliyah Candraning Diyanah Babucarr Jassey Ghina Maulida Rahmah |
| author_facet | Muhammad Rasyid Ridha Ririh Yudhastuti Hari Basuki Notobroto Muhammad Choirul Hidajat Khuliyah Candraning Diyanah Babucarr Jassey Ghina Maulida Rahmah |
| author_sort | Muhammad Rasyid Ridha |
| collection | DOAJ |
| description | Background and Aim: Dengue fever, primarily transmitted by Aedes aegypti, remains a critical public health challenge in Indonesia, with periodic outbreaks exacerbated by widespread insecticide resistance. Resistance to organophosphates and pyrethroids limits vector control efforts, necessitating updated insights into resistance patterns and their genetic underpinnings. This study aimed to evaluate and map insecticide resistance and associated genetic mutations in Ae. aegypti across Indonesia, providing actionable insights for vector management strategies.
Materials and Methods: This systematic review adheres to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, encompassing studies from 2010 to 2023 identified through PubMed, Scopus, EBSCOhost, and Embase. Keywords targeted Ae. aegypti, insecticide classes, resistance, and Indonesian regions. Inclusion criteria focused on field-derived populations subjected to World Health Organization bioassays for organophosphates (malathion and temefos) and pyrethroids (cypermethrin, deltamethrin, etc.), alongside analyses of knockdown resistance (kdr) mutations in the voltage-gated sodium channel (Vgsc) and acetylcholinesterase-1 (Ace-1) genes. Data synthesis included resistance trends, spatial mapping, and allele frequency analyses.
Results: Resistance to malathion and temefos is extensive, with sporadic susceptibility in specific districts. Pyrethroid resistance is pervasive, particularly for cypermethrin and lambda-cyhalothrin, with deltamethrin exhibiting isolated susceptibility. Genetic analyses reveal Vgsc mutations (V1016G, F1534C) as key drivers of pyrethroid resistance, while Ace-1 mutations remain unreported. The evolution of resistance correlates with indiscriminate insecticide usage, urbanization, and climatic factors.
Conclusion: The growing prevalence of insecticide resistance in Ae. aegypti underscores the urgent need for integrated vector management strategies. These should incorporate insecticide rotation, resistance monitoring, and community engagement to mitigate resistance and support sustainable dengue control efforts in Indonesia. |
| format | Article |
| id | doaj-art-ed77f900942246d2a3e3dbb43dcb3a03 |
| institution | OA Journals |
| issn | 0972-8988 2231-0916 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Veterinary World |
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| series | Veterinary World |
| spelling | doaj-art-ed77f900942246d2a3e3dbb43dcb3a032025-08-20T02:12:24ZengVeterinary WorldVeterinary World0972-89882231-09162025-03-0118365867210.14202/vetworld.2025.658-672A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in IndonesiaMuhammad Rasyid Ridha0https://orcid.org/0000-0003-3164-336XRirih Yudhastuti1https://orcid.org/0000-0002-1091-0687Hari Basuki Notobroto2https://orcid.org/0000-0002-3905-7413Muhammad Choirul Hidajat3https://orcid.org/0000-0002-0267-6640Khuliyah Candraning Diyanah4https://orcid.org/0009-0009-2651-5233Babucarr Jassey5https://orcid.org/0000-0001-5913-858XGhina Maulida Rahmah6https://orcid.org/0009-0000-5554-2884Doctorate Degree Program in Public Health, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia; Research Center for Public Health and Nutrition, National Research and Innovation Agency Republic of Indonesia, Jakarta, Indonesia. Department of Environmental Health, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.Department of Epidemiology, Biostatistics, Population Studies and Health Promotion, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.Research Center for Public Health and Nutrition, National Research and Innovation Agency Republic of Indonesia, Jakarta, Indonesia.Department of Environmental Health, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.Doctorate Degree Program in Public Health, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia; Department of Public Health Services, Ministry of Health, Quadrangle, Banjul, The Gambia, 00220, West Africa.Statistics Study Program, Faculty of Mathematics and Natural Sciences, University of Lambung Mangkurat, Banjarbaru, Indonesia.Background and Aim: Dengue fever, primarily transmitted by Aedes aegypti, remains a critical public health challenge in Indonesia, with periodic outbreaks exacerbated by widespread insecticide resistance. Resistance to organophosphates and pyrethroids limits vector control efforts, necessitating updated insights into resistance patterns and their genetic underpinnings. This study aimed to evaluate and map insecticide resistance and associated genetic mutations in Ae. aegypti across Indonesia, providing actionable insights for vector management strategies. Materials and Methods: This systematic review adheres to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, encompassing studies from 2010 to 2023 identified through PubMed, Scopus, EBSCOhost, and Embase. Keywords targeted Ae. aegypti, insecticide classes, resistance, and Indonesian regions. Inclusion criteria focused on field-derived populations subjected to World Health Organization bioassays for organophosphates (malathion and temefos) and pyrethroids (cypermethrin, deltamethrin, etc.), alongside analyses of knockdown resistance (kdr) mutations in the voltage-gated sodium channel (Vgsc) and acetylcholinesterase-1 (Ace-1) genes. Data synthesis included resistance trends, spatial mapping, and allele frequency analyses. Results: Resistance to malathion and temefos is extensive, with sporadic susceptibility in specific districts. Pyrethroid resistance is pervasive, particularly for cypermethrin and lambda-cyhalothrin, with deltamethrin exhibiting isolated susceptibility. Genetic analyses reveal Vgsc mutations (V1016G, F1534C) as key drivers of pyrethroid resistance, while Ace-1 mutations remain unreported. The evolution of resistance correlates with indiscriminate insecticide usage, urbanization, and climatic factors. Conclusion: The growing prevalence of insecticide resistance in Ae. aegypti underscores the urgent need for integrated vector management strategies. These should incorporate insecticide rotation, resistance monitoring, and community engagement to mitigate resistance and support sustainable dengue control efforts in Indonesia.https://www.veterinaryworld.org/Vol.18/March-2025/13.pdfaedes aegyptidengue feverindonesiainsecticide resistanceknockdown resistance mutationsvector control |
| spellingShingle | Muhammad Rasyid Ridha Ririh Yudhastuti Hari Basuki Notobroto Muhammad Choirul Hidajat Khuliyah Candraning Diyanah Babucarr Jassey Ghina Maulida Rahmah A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia Veterinary World aedes aegypti dengue fever indonesia insecticide resistance knockdown resistance mutations vector control |
| title | A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia |
| title_full | A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia |
| title_fullStr | A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia |
| title_full_unstemmed | A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia |
| title_short | A systematic review of insecticide resistance in Aedes aegypti (Diptera: Culicidae) and implications for dengue control in Indonesia |
| title_sort | systematic review of insecticide resistance in aedes aegypti diptera culicidae and implications for dengue control in indonesia |
| topic | aedes aegypti dengue fever indonesia insecticide resistance knockdown resistance mutations vector control |
| url | https://www.veterinaryworld.org/Vol.18/March-2025/13.pdf |
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