GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory
Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to ax...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.19 |
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| _version_ | 1850163814439321600 |
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| author | M. Majchrzak G. Di Scala |
| author_facet | M. Majchrzak G. Di Scala |
| author_sort | M. Majchrzak |
| collection | DOAJ |
| description | Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation. |
| format | Article |
| id | doaj-art-ed762c4e8d344f90a32f2e8935f5465e |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ed762c4e8d344f90a32f2e8935f5465e2025-08-20T02:22:09ZengWileyNeural Plasticity2090-59041687-54432000-01-0171-2192910.1155/NP.2000.19GABA and Muscimol as Reversible Inactivation Tools in Learning and MemoryM. Majchrzak0G. Di Scala1Laboratoire de Neurociences Comportementales et Cognitives LN2C UMR7521 ULP/CNRS, 12 rue Goethe , Strasbourg 67000, FranceLaboratoire de Neurociences Comportementales et Cognitives LN2C UMR7521 ULP/CNRS, 12 rue Goethe , Strasbourg 67000, FranceReversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.http://dx.doi.org/10.1155/NP.2000.19 |
| spellingShingle | M. Majchrzak G. Di Scala GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory Neural Plasticity |
| title | GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory |
| title_full | GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory |
| title_fullStr | GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory |
| title_full_unstemmed | GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory |
| title_short | GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory |
| title_sort | gaba and muscimol as reversible inactivation tools in learning and memory |
| url | http://dx.doi.org/10.1155/NP.2000.19 |
| work_keys_str_mv | AT mmajchrzak gabaandmuscimolasreversibleinactivationtoolsinlearningandmemory AT gdiscala gabaandmuscimolasreversibleinactivationtoolsinlearningandmemory |