GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

Abstract Glioblastoma (GBM) resistance to chemoradiotherapy is a major factor contributing to poor treatment outcomes. This resistance markedly affects the effectiveness of surgery combined with chemoradiotherapy and leads to post‐surgical tumor recurrence. Therefore, exploring the mechanisms underl...

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Bibliographic Details
Main Authors: Yong‐Chang Yang, Xing‐Yu Jin, Ling‐Ling Yang, Xing Xu, Yang Xie, Yi‐Ding Ai, Xin‐Chao Li, Ye‐Cheng Ma, Cheng‐Long Xu, Qi Li, Xiang‐Lian Ge, Tai‐Long Yi, Tao Jiang, Xiao‐Guang Wang, Ying‐Zhe Piao, Xun Jin
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
chemoradiotherapy resistance
glioblastoma
GNE‐317
MSN
PI3K/mTOR
proneural‐to‐mesenchymal transition
Online Access:https://doi.org/10.1002/advs.202412517
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