Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum

Diplazium esculentum commonly known as lsquoVegetable fernrsquo or lsquoPakorsquo holds significant traditional medicinal value across tropical and subtropical regions. This comprehensive review synthesizes existing literature to provide an in-depth exploration of its ethnomedic...

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Main Author: Abhishek Singh
Format: Article
Language:English
Published: Rajiv Gandhi University of Health Sciences 2025-01-01
Series:RGUHS Journal of Medical Sciences
Online Access:https://journalgrid.com/view/article/rjms/12434313
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author Abhishek Singh
author_facet Abhishek Singh
author_sort Abhishek Singh
collection DOAJ
description Diplazium esculentum commonly known as lsquoVegetable fernrsquo or lsquoPakorsquo holds significant traditional medicinal value across tropical and subtropical regions. This comprehensive review synthesizes existing literature to provide an in-depth exploration of its ethnomedicinal pharmacological and phytochemical properties. The ethnomedicinal section elucidates its traditional uses in treating ailments like fever inflammation gastrointestinal disorders and wound healing drawing upon centuries-old indigenous knowledge from diverse cultures. Pharmacologically D. esculentum exhibits multifaceted activities including antioxidant properties antimicrobial effects against a spectrum of pathogens hepatoprotective potential and emerging evidence suggesting antidiabetic activity. Phytochemical analysis reveals the presence of various bioactive compounds notably polyphenols such as flavonoids and phenolic acids triterpenoids alkaloids and saponins which contribute to its therapeutic potential and biological activities. Mechanistic insights delve into molecular pathways elucidating the interactions of D. esculentum bioactives with cellular targets and signalling cascades. Furthermore pharmacokinetic considerations shed light on the absorption distribution metabolism and excretion ADME profiles of its constituents providing critical insights into their bioavailability and pharmacological efficacy. Evaluation of the safety profile through animal studies and clinical trials underscores its potential as a safe therapeutic agent albeit with considerations for dosage and administration. Clinical applications encompass a wide range of conditions including gastrointestinal disorders infectious diseases liver ailments and metabolic disorders suggesting promising avenues for integrative medicine approaches. Formulation strategies and standardization methods are discussed to ensure product quality and consistency while future research directions emphasize the need for mechanistic elucidation clinical validation and sustainable utilization of D. esculentum in both traditional healing practices and modern pharmacotherapy. This review consolidates existing knowledge facilitating a deeper understanding of D. esculentums therapeutic potential and fostering interdisciplinary collaboration for its continued exploration and utilization in global health contexts.
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institution Kabale University
issn 2231-1947
2581-7248
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publisher Rajiv Gandhi University of Health Sciences
record_format Article
series RGUHS Journal of Medical Sciences
spelling doaj-art-ed72b90665814ef7bef4d8cbfdd804582025-02-04T05:52:53ZengRajiv Gandhi University of Health SciencesRGUHS Journal of Medical Sciences2231-19472581-72482025-01-0115110.26463/rjms.15_1_13Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentumAbhishek Singh Diplazium esculentum commonly known as lsquoVegetable fernrsquo or lsquoPakorsquo holds significant traditional medicinal value across tropical and subtropical regions. This comprehensive review synthesizes existing literature to provide an in-depth exploration of its ethnomedicinal pharmacological and phytochemical properties. The ethnomedicinal section elucidates its traditional uses in treating ailments like fever inflammation gastrointestinal disorders and wound healing drawing upon centuries-old indigenous knowledge from diverse cultures. Pharmacologically D. esculentum exhibits multifaceted activities including antioxidant properties antimicrobial effects against a spectrum of pathogens hepatoprotective potential and emerging evidence suggesting antidiabetic activity. Phytochemical analysis reveals the presence of various bioactive compounds notably polyphenols such as flavonoids and phenolic acids triterpenoids alkaloids and saponins which contribute to its therapeutic potential and biological activities. Mechanistic insights delve into molecular pathways elucidating the interactions of D. esculentum bioactives with cellular targets and signalling cascades. Furthermore pharmacokinetic considerations shed light on the absorption distribution metabolism and excretion ADME profiles of its constituents providing critical insights into their bioavailability and pharmacological efficacy. Evaluation of the safety profile through animal studies and clinical trials underscores its potential as a safe therapeutic agent albeit with considerations for dosage and administration. Clinical applications encompass a wide range of conditions including gastrointestinal disorders infectious diseases liver ailments and metabolic disorders suggesting promising avenues for integrative medicine approaches. Formulation strategies and standardization methods are discussed to ensure product quality and consistency while future research directions emphasize the need for mechanistic elucidation clinical validation and sustainable utilization of D. esculentum in both traditional healing practices and modern pharmacotherapy. This review consolidates existing knowledge facilitating a deeper understanding of D. esculentums therapeutic potential and fostering interdisciplinary collaboration for its continued exploration and utilization in global health contexts.https://journalgrid.com/view/article/rjms/12434313
spellingShingle Abhishek Singh
Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
RGUHS Journal of Medical Sciences
title Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
title_full Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
title_fullStr Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
title_full_unstemmed Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
title_short Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
title_sort ethnomedicinal pharmacological and phytochemical overview of diplazium esculentum
url https://journalgrid.com/view/article/rjms/12434313
work_keys_str_mv AT abhisheksingh ethnomedicinalpharmacologicalandphytochemicaloverviewofdiplaziumesculentum