Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite
Obesity has brought great challenges to global human health, and how to effectively prevent and control the occurrence and development of obesity has become an urgent problem. The role and mechanism of 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate (MITC), an active ingredient of Moringa oleifera Lam....
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Tsinghua University Press
2025-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250328 |
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| author | Jing Xie Zishan Hong Jiaying Mao Linjie Peng Yuying Bai Jun Sheng Yang Tian |
| author_facet | Jing Xie Zishan Hong Jiaying Mao Linjie Peng Yuying Bai Jun Sheng Yang Tian |
| author_sort | Jing Xie |
| collection | DOAJ |
| description | Obesity has brought great challenges to global human health, and how to effectively prevent and control the occurrence and development of obesity has become an urgent problem. The role and mechanism of 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate (MITC), an active ingredient of Moringa oleifera Lam., in the regulation of lipid metabolism have not been comprehensively investigated. In the present study, we investigated the mechanism of MITC in inhibiting lipid accumulation in mice fed with a high-fat diet (HFD) in terms of both lipolysis and central appetite regulation mediated by the gut microbe-gut-brain axis. MITC enhanced the characteristic indices associated with HFD mice and also promoted adipocytolysis and brown fat thermogenesis. Moreover, MITC was observed to improve leptin resistance, modulate the composition of gut microbiota such as Ruminococcaceae, Parasutterella, and Acetatifactor, promote 5-hydroxytryptamine secretion, further enhance the secretion of glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) to activate peroxisome proliferator-activated receptor (PPAR) signaling in the hypothalamus, and modulate feeding behavior to inhibit lipid accumulation in HFD mice. These data suggest that MITC supplementation can help to alleviate obesity or obesity-related diseases. |
| format | Article |
| id | doaj-art-ed71e4ecfc6b4b8ca0dceef77e97f932 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-ed71e4ecfc6b4b8ca0dceef77e97f9322025-08-20T03:41:14ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-07-01147925032810.26599/FSHW.2024.9250328Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetiteJing Xie0Zishan Hong1Jiaying Mao2Linjie Peng3Yuying Bai4Jun Sheng5Yang Tian6College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510640, ChinaCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaYunnan Provincial Key Laboratory of Precision Nutrition and Personalized Food Manufacturing, Yunnan Agricultural University, Kunming 650201, ChinaCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, ChinaObesity has brought great challenges to global human health, and how to effectively prevent and control the occurrence and development of obesity has become an urgent problem. The role and mechanism of 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate (MITC), an active ingredient of Moringa oleifera Lam., in the regulation of lipid metabolism have not been comprehensively investigated. In the present study, we investigated the mechanism of MITC in inhibiting lipid accumulation in mice fed with a high-fat diet (HFD) in terms of both lipolysis and central appetite regulation mediated by the gut microbe-gut-brain axis. MITC enhanced the characteristic indices associated with HFD mice and also promoted adipocytolysis and brown fat thermogenesis. Moreover, MITC was observed to improve leptin resistance, modulate the composition of gut microbiota such as Ruminococcaceae, Parasutterella, and Acetatifactor, promote 5-hydroxytryptamine secretion, further enhance the secretion of glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) to activate peroxisome proliferator-activated receptor (PPAR) signaling in the hypothalamus, and modulate feeding behavior to inhibit lipid accumulation in HFD mice. These data suggest that MITC supplementation can help to alleviate obesity or obesity-related diseases.https://www.sciopen.com/article/10.26599/FSHW.2024.9250328moringa oleiferaisothiocyanateslipid accumulationlipolysisappetite |
| spellingShingle | Jing Xie Zishan Hong Jiaying Mao Linjie Peng Yuying Bai Jun Sheng Yang Tian Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite Food Science and Human Wellness moringa oleifera isothiocyanates lipid accumulation lipolysis appetite |
| title | Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite |
| title_full | Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite |
| title_fullStr | Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite |
| title_full_unstemmed | Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite |
| title_short | Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite |
| title_sort | moringa oleifera lam isothiocyanate inhibits lipid accumulation in high fat diet mice by promoting lipid metabolism and modulating appetite |
| topic | moringa oleifera isothiocyanates lipid accumulation lipolysis appetite |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250328 |
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