COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study
Abstract Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vac...
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2024-12-01
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| author | Carmen Infante-Domínguez Sonsoles Salto-Alejandre Rocío Álvarez-Marín Nuria Sabé Antonio Ramos-Martínez Asunción Moreno Kamilla Ferreira de Moraes Zaira R. Palacios-Baena Patricia Muñoz Mario Fernández-Ruiz Marino Blanes Carmen Fariñas Elisa Vidal Esperanza Merino de Lucas Márcia Halpern Román Hernández-Gallego Matteo Bassetti Alessandra Mularoni Alex Gutiérrez-Dalmau Matteo Rinaldi Silvia Jiménez-Jorge Marta Bodro Luis Fernando Aranha-Camargo Maricela Valerio Javier Sánchez-Céspedes Belén Gutiérrez-Gutiérrez Maddalena Giannella Jesús Rodríguez-Baño Jerónimo Pachón Elisa Cordero The COVIDSOT, ORCHESTRA Working Teams |
| author_facet | Carmen Infante-Domínguez Sonsoles Salto-Alejandre Rocío Álvarez-Marín Nuria Sabé Antonio Ramos-Martínez Asunción Moreno Kamilla Ferreira de Moraes Zaira R. Palacios-Baena Patricia Muñoz Mario Fernández-Ruiz Marino Blanes Carmen Fariñas Elisa Vidal Esperanza Merino de Lucas Márcia Halpern Román Hernández-Gallego Matteo Bassetti Alessandra Mularoni Alex Gutiérrez-Dalmau Matteo Rinaldi Silvia Jiménez-Jorge Marta Bodro Luis Fernando Aranha-Camargo Maricela Valerio Javier Sánchez-Céspedes Belén Gutiérrez-Gutiérrez Maddalena Giannella Jesús Rodríguez-Baño Jerónimo Pachón Elisa Cordero The COVIDSOT, ORCHESTRA Working Teams |
| author_sort | Carmen Infante-Domínguez |
| collection | DOAJ |
| description | Abstract Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51–69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO2 < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-ed6fb698d29b4e1499dcaff9b14f16ae2025-08-20T02:31:00ZengNature PortfolioScientific Reports2045-23222024-12-0114111310.1038/s41598-024-81099-2COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation studyCarmen Infante-Domínguez0Sonsoles Salto-Alejandre1Rocío Álvarez-Marín2Nuria Sabé3Antonio Ramos-Martínez4Asunción Moreno5Kamilla Ferreira de Moraes6Zaira R. Palacios-Baena7Patricia Muñoz8Mario Fernández-Ruiz9Marino Blanes10Carmen Fariñas11Elisa Vidal12Esperanza Merino de Lucas13Márcia Halpern14Román Hernández-Gallego15Matteo Bassetti16Alessandra Mularoni17Alex Gutiérrez-Dalmau18Matteo Rinaldi19Silvia Jiménez-Jorge20Marta Bodro21Luis Fernando Aranha-Camargo22Maricela Valerio23Javier Sánchez-Céspedes24Belén Gutiérrez-Gutiérrez25Maddalena Giannella26Jesús Rodríguez-Baño27Jerónimo Pachón28Elisa Cordero29The COVIDSOT, ORCHESTRA Working TeamsClinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of SevilleClinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of SevilleClinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of SevilleCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIUnit of Infectious Diseases, Microbiology, and Preventive Medicine. Hospital, Universitario Puerta de Hierro-Majadahonda-IDIPHISAService of Infectious Diseases, Hospital Clinic-IDIBAPS. University of BarcelonaHospital Israelita Albert EinsteinCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERES, ISCIII-CIBER de Enfermedades Respiratorias. Medicine Department, School of Medicine, Universidad Complutense de MadridCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIUnit of Infectious Diseases, La Fe University HospitalCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIICIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIUnit of Infectious Diseases, Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL)Liver Transplantation Program, Quinta D’Or HospitalUnit of Kidney Transplant, Service of Nephrology, Badajoz University HospitalInfectious Diseases Clinic, Policlinico San Martino Hospital-IRCCS, Department of Health Science, University of GenoaUnit of Infectious Diseases and Infection Control, ISMETT-IRCCS-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione-Istituto di Ricovero e Cura a Carattere ScientificoRenal Transplant Unit, Nephrology Service, Miguel Servet University Hospital, Aragón Institute for Health Research IIS-AragónDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of BolognaClinical Research and Clinical Trials Unit (CTU), Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital/CSIC/University of SevilleService of Infectious Diseases, Hospital Clinic-IDIBAPS. University of BarcelonaHospital Israelita Albert EinsteinClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERES, ISCIII-CIBER de Enfermedades Respiratorias. Medicine Department, School of Medicine, Universidad Complutense de MadridClinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of SevilleCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of BolognaCIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos IIIDepartment of Medicine, School of Medicine, University of SevilleClinical Unit of Infectious Diseases, Microbiology and Parasitology, Instituto de Biomedicina de Sevilla (IBiS), Virgen del Rocío University Hospital /CSIC/University of SevilleAbstract Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51–69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO2 < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.https://doi.org/10.1038/s41598-024-81099-2Solid organ transplant recipientsCOVID-19Clinical phenotypesMortalityMulticenter cohort study |
| spellingShingle | Carmen Infante-Domínguez Sonsoles Salto-Alejandre Rocío Álvarez-Marín Nuria Sabé Antonio Ramos-Martínez Asunción Moreno Kamilla Ferreira de Moraes Zaira R. Palacios-Baena Patricia Muñoz Mario Fernández-Ruiz Marino Blanes Carmen Fariñas Elisa Vidal Esperanza Merino de Lucas Márcia Halpern Román Hernández-Gallego Matteo Bassetti Alessandra Mularoni Alex Gutiérrez-Dalmau Matteo Rinaldi Silvia Jiménez-Jorge Marta Bodro Luis Fernando Aranha-Camargo Maricela Valerio Javier Sánchez-Céspedes Belén Gutiérrez-Gutiérrez Maddalena Giannella Jesús Rodríguez-Baño Jerónimo Pachón Elisa Cordero The COVIDSOT, ORCHESTRA Working Teams COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study Scientific Reports Solid organ transplant recipients COVID-19 Clinical phenotypes Mortality Multicenter cohort study |
| title | COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study |
| title_full | COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study |
| title_fullStr | COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study |
| title_full_unstemmed | COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study |
| title_short | COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study |
| title_sort | covid 19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients a multicenter validation study |
| topic | Solid organ transplant recipients COVID-19 Clinical phenotypes Mortality Multicenter cohort study |
| url | https://doi.org/10.1038/s41598-024-81099-2 |
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