M2 macrophage-derived extracellular vesicles protect against abdominal aortic aneurysm by modulating macrophage polarization through miR221-5p

M2 macrophage-derived extracellular vesicles protect against abdominal aortic aneurysm by modulating macrophage polarization through miR221-5p

Abstract Background Extracellular vesicles (EVs) derived from M2 macrophages (M2-EVs) play a protective role in the pathogenesis of acute lung injury. However, their roles and mechanisms in abdominal aortic aneurysm (AAA) are unknown. Methods The effects of M2-EVs in AAA were examined in ApoE−/− mic...

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Main Authors: Yang Ma, Xiang-jiu Ding, Si-yu Lu, Xiao-fang Huang, Yuan-yuan Hu, Han Liu, Bin Liu, Ke-yin Liu, Ming-xiang Zhang, Hao Wang, Feng Xu, Wei-dong Qin
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Abdominal aortic aneurysm
M2 macrophages
Extracellular vesicles
microRNA 221-5p
Macrophage polarization
Online Access:https://doi.org/10.1186/s11658-025-00768-w
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