Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice
Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunctio...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3736912 |
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| _version_ | 1849690885111939072 |
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| author | Xiaoxin Zhou Jian Lu Tong Wu Xuliang Jiang Weitian Tian Wanbing Dai Siyi Qi Xuemei Chen Jiaqiang Zhang Diansan Su |
| author_facet | Xiaoxin Zhou Jian Lu Tong Wu Xuliang Jiang Weitian Tian Wanbing Dai Siyi Qi Xuemei Chen Jiaqiang Zhang Diansan Su |
| author_sort | Xiaoxin Zhou |
| collection | DOAJ |
| description | Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF-α in the hippocampus after multiple operations and the activation of microglia, multiple anesthesia/surgery did not cause a decline in cognitive function in adult mice. There were no changes in the cholinergic markers after multiple anesthesia/surgery. |
| format | Article |
| id | doaj-art-ed694927cd5f418a9fdb8645848696ec |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ed694927cd5f418a9fdb8645848696ec2025-08-20T03:21:11ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/37369123736912Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult MiceXiaoxin Zhou0Jian Lu1Tong Wu2Xuliang Jiang3Weitian Tian4Wanbing Dai5Siyi Qi6Xuemei Chen7Jiaqiang Zhang8Diansan Su9Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaDepartment of Anesthesiology and Perioperative Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaPostoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF-α in the hippocampus after multiple operations and the activation of microglia, multiple anesthesia/surgery did not cause a decline in cognitive function in adult mice. There were no changes in the cholinergic markers after multiple anesthesia/surgery.http://dx.doi.org/10.1155/2020/3736912 |
| spellingShingle | Xiaoxin Zhou Jian Lu Tong Wu Xuliang Jiang Weitian Tian Wanbing Dai Siyi Qi Xuemei Chen Jiaqiang Zhang Diansan Su Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice Mediators of Inflammation |
| title | Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice |
| title_full | Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice |
| title_fullStr | Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice |
| title_full_unstemmed | Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice |
| title_short | Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice |
| title_sort | multiple anesthesia surgery cannot impair reference memory in adult mice |
| url | http://dx.doi.org/10.1155/2020/3736912 |
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