Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis
Objective. This study is aimed at evaluating the survival of cirrhotic patients with different etiologies after endoscopic therapy for acute variceal bleeding and the effect of repeated endotherapy on patients’ prognosis. Methods. We retrospectively evaluated the clinical features and outcomes betwe...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/5747563 |
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| author | Jia-li Ma Ling-ling He Ping Li Yu Jiang Ju-long Hu Yu-ling Zhou Xiu-xia Liang Hong-shan Wei |
| author_facet | Jia-li Ma Ling-ling He Ping Li Yu Jiang Ju-long Hu Yu-ling Zhou Xiu-xia Liang Hong-shan Wei |
| author_sort | Jia-li Ma |
| collection | DOAJ |
| description | Objective. This study is aimed at evaluating the survival of cirrhotic patients with different etiologies after endoscopic therapy for acute variceal bleeding and the effect of repeated endotherapy on patients’ prognosis. Methods. We retrospectively evaluated the clinical features and outcomes between cirrhotic patients with chronic HBV or HCV infections and other etiologies. The 3-year and 5-year survival rates and rehemorrhage rate in one year between the viral and nonviral cirrhosis patients were compared by Kaplan-Meier curves and log-rank test. Cox analysis was used to identify the impact factors that affect the long-term survival of patients with cirrhosis and variceal bleeding after endotherapy. Results. Out of 2665 patients with liver cirrhosis and variceal hemorrhage selected from our medical center between September 2008 and December 2017, a total of 1342 patients were included for analysis. The median follow-up duration was 32.9 months (range 0.16-111.4 months), the 3- and 5-year cumulative survival rates were 75.3% and 52.8%, respectively. The median survival time was significantly longer in viral cirrhosis patients (47.1 months [95% CI: 24.9-69.1]) compared with nonviral cirrhosis patients (37.0 months [95% CI: 25.0-56.0], p=0.001). The 3-year and 5-year survival rates of the viral group were higher than the nonviral group. The rehemorrhage rate at one year was higher in nonviral patients than in viral patients (p<0.001). Conclusion. Repeated endotherapy combined with effective antiviral therapy is helpful for long-term survival of cirrhotic population with variceal hemorrhage and HBV or HCV infection. |
| format | Article |
| id | doaj-art-ed610b086da14306b4e5f3d512231509 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ed610b086da14306b4e5f3d5122315092025-02-03T06:04:37ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/57475635747563Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World AnalysisJia-li Ma0Ling-ling He1Ping Li2Yu Jiang3Ju-long Hu4Yu-ling Zhou5Xiu-xia Liang6Hong-shan Wei7Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaObjective. This study is aimed at evaluating the survival of cirrhotic patients with different etiologies after endoscopic therapy for acute variceal bleeding and the effect of repeated endotherapy on patients’ prognosis. Methods. We retrospectively evaluated the clinical features and outcomes between cirrhotic patients with chronic HBV or HCV infections and other etiologies. The 3-year and 5-year survival rates and rehemorrhage rate in one year between the viral and nonviral cirrhosis patients were compared by Kaplan-Meier curves and log-rank test. Cox analysis was used to identify the impact factors that affect the long-term survival of patients with cirrhosis and variceal bleeding after endotherapy. Results. Out of 2665 patients with liver cirrhosis and variceal hemorrhage selected from our medical center between September 2008 and December 2017, a total of 1342 patients were included for analysis. The median follow-up duration was 32.9 months (range 0.16-111.4 months), the 3- and 5-year cumulative survival rates were 75.3% and 52.8%, respectively. The median survival time was significantly longer in viral cirrhosis patients (47.1 months [95% CI: 24.9-69.1]) compared with nonviral cirrhosis patients (37.0 months [95% CI: 25.0-56.0], p=0.001). The 3-year and 5-year survival rates of the viral group were higher than the nonviral group. The rehemorrhage rate at one year was higher in nonviral patients than in viral patients (p<0.001). Conclusion. Repeated endotherapy combined with effective antiviral therapy is helpful for long-term survival of cirrhotic population with variceal hemorrhage and HBV or HCV infection.http://dx.doi.org/10.1155/2020/5747563 |
| spellingShingle | Jia-li Ma Ling-ling He Ping Li Yu Jiang Ju-long Hu Yu-ling Zhou Xiu-xia Liang Hong-shan Wei Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis Gastroenterology Research and Practice |
| title | Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis |
| title_full | Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis |
| title_fullStr | Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis |
| title_full_unstemmed | Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis |
| title_short | Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis |
| title_sort | clinical features and outcomes of repeated endoscopic therapy for esophagogastric variceal hemorrhage in cirrhotic patients ten year real world analysis |
| url | http://dx.doi.org/10.1155/2020/5747563 |
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