Voxel-Based Lesion Analysis of Ideomotor Apraxia
Ideomotor apraxia is a cognitive disorder most often resulting from acquired brain lesions (i.e., strokes or tumors). Neuroimaging and lesion studies have implicated several brain regions in praxis and apraxia, but most studies have described (sub)acute patients. This study aimed to extend previous...
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MDPI AG
2024-08-01
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| Online Access: | https://www.mdpi.com/2076-3425/14/9/853 |
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| author | Giovanna Oliveira Santos Analía L. Arévalo Timothy J. Herron Brian C. Curran Guilherme Lepski Nina F. Dronkers Juliana V. Baldo |
| author_facet | Giovanna Oliveira Santos Analía L. Arévalo Timothy J. Herron Brian C. Curran Guilherme Lepski Nina F. Dronkers Juliana V. Baldo |
| author_sort | Giovanna Oliveira Santos |
| collection | DOAJ |
| description | Ideomotor apraxia is a cognitive disorder most often resulting from acquired brain lesions (i.e., strokes or tumors). Neuroimaging and lesion studies have implicated several brain regions in praxis and apraxia, but most studies have described (sub)acute patients. This study aimed to extend previous research by analyzing data from 115 left hemisphere chronic stroke patients using the praxis subtest of the Western Aphasia Battery, which is divided into four action types: facial, upper limb, complex, and instrumental. Lesion–symptom mapping was used to identify brain regions most critically associated with difficulties in each of the four subtests. Complex and instrumental action deficits were associated with left precentral, postcentral, and superior parietal gyri (Brodmann areas 2, 3, 4, 5, and 6), while the facial and upper limb action deficits maps were restricted to left inferior, middle, and medial temporal gyri (Brodmann areas 20, 21, 22, and 48). We discuss ideas about neuroplasticity and cortical reorganization in chronic stroke and how different methodologies can reveal different aspects of lesion and recovery networks in apraxia. |
| format | Article |
| id | doaj-art-ed5b03a20b084e6a8439c7dbbcac7cfc |
| institution | OA Journals |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-ed5b03a20b084e6a8439c7dbbcac7cfc2025-08-20T01:56:05ZengMDPI AGBrain Sciences2076-34252024-08-0114985310.3390/brainsci14090853Voxel-Based Lesion Analysis of Ideomotor ApraxiaGiovanna Oliveira Santos0Analía L. Arévalo1Timothy J. Herron2Brian C. Curran3Guilherme Lepski4Nina F. Dronkers5Juliana V. Baldo6Department of Experimental Surgery, Medical School, University of São Paulo, Sao Paulo 05021-001, BrazilDepartment of Experimental Surgery, Medical School, University of São Paulo, Sao Paulo 05021-001, BrazilResearch Service, VA Northern California Health Care System, Martinez, CA 94553, USAResearch Service, VA Northern California Health Care System, Martinez, CA 94553, USADepartment of Experimental Surgery, Medical School, University of São Paulo, Sao Paulo 05021-001, BrazilDepartment of Psychology, University of California, Berkeley, Berkeley, CA 94720, USAResearch Service, VA Northern California Health Care System, Martinez, CA 94553, USAIdeomotor apraxia is a cognitive disorder most often resulting from acquired brain lesions (i.e., strokes or tumors). Neuroimaging and lesion studies have implicated several brain regions in praxis and apraxia, but most studies have described (sub)acute patients. This study aimed to extend previous research by analyzing data from 115 left hemisphere chronic stroke patients using the praxis subtest of the Western Aphasia Battery, which is divided into four action types: facial, upper limb, complex, and instrumental. Lesion–symptom mapping was used to identify brain regions most critically associated with difficulties in each of the four subtests. Complex and instrumental action deficits were associated with left precentral, postcentral, and superior parietal gyri (Brodmann areas 2, 3, 4, 5, and 6), while the facial and upper limb action deficits maps were restricted to left inferior, middle, and medial temporal gyri (Brodmann areas 20, 21, 22, and 48). We discuss ideas about neuroplasticity and cortical reorganization in chronic stroke and how different methodologies can reveal different aspects of lesion and recovery networks in apraxia.https://www.mdpi.com/2076-3425/14/9/853chronic strokeleft hemisphere lesionslesion–symptom mappingpraxiswestern aphasia battery |
| spellingShingle | Giovanna Oliveira Santos Analía L. Arévalo Timothy J. Herron Brian C. Curran Guilherme Lepski Nina F. Dronkers Juliana V. Baldo Voxel-Based Lesion Analysis of Ideomotor Apraxia Brain Sciences chronic stroke left hemisphere lesions lesion–symptom mapping praxis western aphasia battery |
| title | Voxel-Based Lesion Analysis of Ideomotor Apraxia |
| title_full | Voxel-Based Lesion Analysis of Ideomotor Apraxia |
| title_fullStr | Voxel-Based Lesion Analysis of Ideomotor Apraxia |
| title_full_unstemmed | Voxel-Based Lesion Analysis of Ideomotor Apraxia |
| title_short | Voxel-Based Lesion Analysis of Ideomotor Apraxia |
| title_sort | voxel based lesion analysis of ideomotor apraxia |
| topic | chronic stroke left hemisphere lesions lesion–symptom mapping praxis western aphasia battery |
| url | https://www.mdpi.com/2076-3425/14/9/853 |
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