Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma
We assessed the efficacy of the lung immune prognostic index (LIPI) in predicting the progression of pathological T3 renal cell carcinoma (RCC). The LIPI scores of patients with pathological T3 RCC were calculated in the pre- and post-operative phases. Patients were divided into zero-point, one-poin...
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MDPI AG
2025-06-01
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| Series: | Current Oncology |
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| author | Hayato Hoshina Toru Sugihara Masayuki Kurokawa Ei-ichiro Takaoka Satoshi Ando Haruki Kume Tetsuya Fujimura |
| author_facet | Hayato Hoshina Toru Sugihara Masayuki Kurokawa Ei-ichiro Takaoka Satoshi Ando Haruki Kume Tetsuya Fujimura |
| author_sort | Hayato Hoshina |
| collection | DOAJ |
| description | We assessed the efficacy of the lung immune prognostic index (LIPI) in predicting the progression of pathological T3 renal cell carcinoma (RCC). The LIPI scores of patients with pathological T3 RCC were calculated in the pre- and post-operative phases. Patients were divided into zero-point, one-point, and two-point groups according to their LIPI score and into the upstage and non-upstage groups according to the pre- and post-operative increase in LIPI score. Overall survival (OS) was evaluated using Kaplan–Meier curves stratified by group. Univariate and multivariate analyses of OS were performed via Cox proportional hazard regression analysis. LIPI scores were calculated in 80 patients wherein blood sampling data were available. The upstage and non-upstage groups comprised eight and seventy-two patients, respectively. Kaplan–Meier curves showed a significant difference in the pre- to post-operative LIPI score upstage group. LIPI score change was a poor prognostic factor using univariate analysis (OS: hazard ratio (HR) = 4.10, 95% confidence interval (CI) = 1.07–15.61, <i>p</i> = 0.038) and multivariate analysis (OS: HR = 4.38, 95% CI = 1.13–16.89, <i>p</i> = 0.031). An increase in the LIPI score in the pre-operative phase was a poor prognostic factor for pathological T3 RCC. |
| format | Article |
| id | doaj-art-ed51792bdc2c486fbf65c11dc8363f96 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Current Oncology |
| spelling | doaj-art-ed51792bdc2c486fbf65c11dc8363f962025-08-20T03:24:32ZengMDPI AGCurrent Oncology1198-00521718-77292025-06-0132633510.3390/curroncol32060335Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell CarcinomaHayato Hoshina0Toru Sugihara1Masayuki Kurokawa2Ei-ichiro Takaoka3Satoshi Ando4Haruki Kume5Tetsuya Fujimura6Department of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanDepartment of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanDepartment of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanDepartment of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanDepartment of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8657, JapanDepartment of Urology, Jichi Medical University Hospital, Shimotsuke 329-0498, JapanWe assessed the efficacy of the lung immune prognostic index (LIPI) in predicting the progression of pathological T3 renal cell carcinoma (RCC). The LIPI scores of patients with pathological T3 RCC were calculated in the pre- and post-operative phases. Patients were divided into zero-point, one-point, and two-point groups according to their LIPI score and into the upstage and non-upstage groups according to the pre- and post-operative increase in LIPI score. Overall survival (OS) was evaluated using Kaplan–Meier curves stratified by group. Univariate and multivariate analyses of OS were performed via Cox proportional hazard regression analysis. LIPI scores were calculated in 80 patients wherein blood sampling data were available. The upstage and non-upstage groups comprised eight and seventy-two patients, respectively. Kaplan–Meier curves showed a significant difference in the pre- to post-operative LIPI score upstage group. LIPI score change was a poor prognostic factor using univariate analysis (OS: hazard ratio (HR) = 4.10, 95% confidence interval (CI) = 1.07–15.61, <i>p</i> = 0.038) and multivariate analysis (OS: HR = 4.38, 95% CI = 1.13–16.89, <i>p</i> = 0.031). An increase in the LIPI score in the pre-operative phase was a poor prognostic factor for pathological T3 RCC.https://www.mdpi.com/1718-7729/32/6/335lung immune prognostic indexprognostic factorrenal cell carcinomaT3immune biomarkers |
| spellingShingle | Hayato Hoshina Toru Sugihara Masayuki Kurokawa Ei-ichiro Takaoka Satoshi Ando Haruki Kume Tetsuya Fujimura Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma Current Oncology lung immune prognostic index prognostic factor renal cell carcinoma T3 immune biomarkers |
| title | Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma |
| title_full | Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma |
| title_fullStr | Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma |
| title_full_unstemmed | Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma |
| title_short | Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma |
| title_sort | increased pre operative lung immune prognostic index score is a prognostic factor in cases of pathological t3 renal cell carcinoma |
| topic | lung immune prognostic index prognostic factor renal cell carcinoma T3 immune biomarkers |
| url | https://www.mdpi.com/1718-7729/32/6/335 |
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