Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115
The paper presents the results of experimental studies of pharmacokinetics GB-115 after oral administration of crystalline and micronized substances and 4 new laboratory samples pharmaceutical compositions which differ in the technology of preparation and composition of excipients. It is shown that...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2014-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/154 |
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| author | V. P. Zherdev S. S. Boyko E. V. Blynskaya K. G. Turchinskaya T. A. Gudasheva E. V. Ivannikova |
| author_facet | V. P. Zherdev S. S. Boyko E. V. Blynskaya K. G. Turchinskaya T. A. Gudasheva E. V. Ivannikova |
| author_sort | V. P. Zherdev |
| collection | DOAJ |
| description | The paper presents the results of experimental studies of pharmacokinetics GB-115 after oral administration of crystalline and micronized substances and 4 new laboratory samples pharmaceutical compositions which differ in the technology of preparation and composition of excipients. It is shown that different excipients and preparation technology significantly affect the pharmacokinetics and effect of studied dipeptide; its optimization is improve the pharmacokinetics properties of the developed compound, namely increasing completeness of absorption, maximum concentration, rate and extent of absorption in the final result in bioavailability GB-115. On the basis of experimental data obtained two pharmaceutical compositions recommended for further pharmacological study. |
| format | Article |
| id | doaj-art-ed4d49000dc641ccb4e2efbcf5999c4d |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2014-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-ed4d49000dc641ccb4e2efbcf5999c4d2025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302014-04-01015259153Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115V. P. Zherdev0S. S. Boyko1E. V. Blynskaya2K. G. Turchinskaya3T. A. Gudasheva4E. V. Ivannikova5FGBNI «Research Institute of Pharmacology V.V. Zakusov»FGBNI «Research Institute of Pharmacology V.V. Zakusov»FGBNI «Research Institute of Pharmacology V.V. Zakusov»FGBNI «Research Institute of Pharmacology V.V. Zakusov»FGBNI «Research Institute of Pharmacology V.V. Zakusov»FGBNI «Research Institute of Pharmacology V.V. Zakusov»The paper presents the results of experimental studies of pharmacokinetics GB-115 after oral administration of crystalline and micronized substances and 4 new laboratory samples pharmaceutical compositions which differ in the technology of preparation and composition of excipients. It is shown that different excipients and preparation technology significantly affect the pharmacokinetics and effect of studied dipeptide; its optimization is improve the pharmacokinetics properties of the developed compound, namely increasing completeness of absorption, maximum concentration, rate and extent of absorption in the final result in bioavailability GB-115. On the basis of experimental data obtained two pharmaceutical compositions recommended for further pharmacological study.https://www.pharmacokinetica.ru/jour/article/view/154фармакокинетикалекарственная композициядипептид гб-115микронизированная субстанциявспомогательные веществаpharmacokineticsdrug compositiondipeptide gb-115micronized substance |
| spellingShingle | V. P. Zherdev S. S. Boyko E. V. Blynskaya K. G. Turchinskaya T. A. Gudasheva E. V. Ivannikova Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 Фармакокинетика и Фармакодинамика фармакокинетика лекарственная композиция дипептид гб-115 микронизированная субстанция вспомогательные вещества pharmacokinetics drug composition dipeptide gb-115 micronized substance |
| title | Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 |
| title_full | Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 |
| title_fullStr | Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 |
| title_full_unstemmed | Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 |
| title_short | Preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure GB-115 |
| title_sort | preclinical study the pharmacokinetics new anxiolytic drug of dipeptide structure gb 115 |
| topic | фармакокинетика лекарственная композиция дипептид гб-115 микронизированная субстанция вспомогательные вещества pharmacokinetics drug composition dipeptide gb-115 micronized substance |
| url | https://www.pharmacokinetica.ru/jour/article/view/154 |
| work_keys_str_mv | AT vpzherdev preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 AT ssboyko preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 AT evblynskaya preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 AT kgturchinskaya preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 AT tagudasheva preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 AT evivannikova preclinicalstudythepharmacokineticsnewanxiolyticdrugofdipeptidestructuregb115 |