A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats
An experimental protocol is described aiming to explore the influence of Type 2 Diabetes Mellitus on the biomechanical response of the bone tissue and, also, to quantify the potential beneficial role of a pharmaceutical treatment, based on sitagliptin, a diabetes drug that increases the levels of...
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| Format: | Article |
| Language: | English |
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Gruppo Italiano Frattura
2020-01-01
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| Series: | Fracture and Structural Integrity |
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| Online Access: | https://www.fracturae.com/index.php/fis/article/view/2657 |
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| author | Stavros K Kourkoulis Ermioni Pasiou Arezoo Abdi Despoina Perrea John Vlamis |
| author_facet | Stavros K Kourkoulis Ermioni Pasiou Arezoo Abdi Despoina Perrea John Vlamis |
| author_sort | Stavros K Kourkoulis |
| collection | DOAJ |
| description | An experimental protocol is described aiming to explore the influence of Type 2 Diabetes Mellitus on the biomechanical response of the bone tissue and, also, to quantify the potential beneficial role of a pharmaceutical treatment, based on sitagliptin, a diabetes drug that increases the levels of natural substances called incretins. Twenty eight male, 10-week old Wistar rats were used, divided into three groups, i.e., the control one, the group including the diabetic rats and, finally, the group including the diabetic rats which were treated using sitagliptin. The biomechanical study was based on a series of three-point bending tests of the femora of the sacrificed rats and the analysis of the experimental data was implemented in terms of the actual geometry of the fractured cross-section. It was concluded that diabetic bones undertake larger forces despite the fact that the “diameter” of their cross-section was somehow smaller. On the contrary, the slope of the load-deflection curve (corresponding to a measure of the stiffness) of diabetic bones is slightly lower compared to the control bones. Finally, it seems that treating diabetic animals with sitagliptin only partly reverses the effect of Type 2 Diabetes Mellitus on their bone tissue, at least concerning its strength and stiffness. |
| format | Article |
| id | doaj-art-ed495fbddbfd4a4cbca5ba8bd68917d1 |
| institution | Kabale University |
| issn | 1971-8993 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Gruppo Italiano Frattura |
| record_format | Article |
| series | Fracture and Structural Integrity |
| spelling | doaj-art-ed495fbddbfd4a4cbca5ba8bd68917d12025-01-02T23:01:35ZengGruppo Italiano FratturaFracture and Structural Integrity1971-89932020-01-01145112713510.3221/IGF-ESIS.51.102657A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic ratsStavros K Kourkoulis0Ermioni Pasiou1Arezoo AbdiDespoina PerreaJohn VlamisNational Technical University of Athens, GreeceNational Technical University of AthensAn experimental protocol is described aiming to explore the influence of Type 2 Diabetes Mellitus on the biomechanical response of the bone tissue and, also, to quantify the potential beneficial role of a pharmaceutical treatment, based on sitagliptin, a diabetes drug that increases the levels of natural substances called incretins. Twenty eight male, 10-week old Wistar rats were used, divided into three groups, i.e., the control one, the group including the diabetic rats and, finally, the group including the diabetic rats which were treated using sitagliptin. The biomechanical study was based on a series of three-point bending tests of the femora of the sacrificed rats and the analysis of the experimental data was implemented in terms of the actual geometry of the fractured cross-section. It was concluded that diabetic bones undertake larger forces despite the fact that the “diameter” of their cross-section was somehow smaller. On the contrary, the slope of the load-deflection curve (corresponding to a measure of the stiffness) of diabetic bones is slightly lower compared to the control bones. Finally, it seems that treating diabetic animals with sitagliptin only partly reverses the effect of Type 2 Diabetes Mellitus on their bone tissue, at least concerning its strength and stiffness.https://www.fracturae.com/index.php/fis/article/view/2657male wistar ratstype-2 diabetessitagliptinbiomechanicsthree point bendingvideo-extensometer |
| spellingShingle | Stavros K Kourkoulis Ermioni Pasiou Arezoo Abdi Despoina Perrea John Vlamis A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats Fracture and Structural Integrity male wistar rats type-2 diabetes sitagliptin biomechanics three point bending video-extensometer |
| title | A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| title_full | A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| title_fullStr | A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| title_full_unstemmed | A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| title_short | A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| title_sort | biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats |
| topic | male wistar rats type-2 diabetes sitagliptin biomechanics three point bending video-extensometer |
| url | https://www.fracturae.com/index.php/fis/article/view/2657 |
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