Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosam...
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Format: | Article |
Language: | English |
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Wiley
2018-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2018/5491797 |
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author | Eun Jung Kyung Hyun Bum Kim Eun Sang Hwang Seok Lee Bup Kyung Choi Jin Woong Kim Hyung Joong Kim Sang Moo Lim Oh In Kwon Eung Je Woo |
author_facet | Eun Jung Kyung Hyun Bum Kim Eun Sang Hwang Seok Lee Bup Kyung Choi Jin Woong Kim Hyung Joong Kim Sang Moo Lim Oh In Kwon Eung Je Woo |
author_sort | Eun Jung Kyung |
collection | DOAJ |
description | In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin’s anti-inflammatory effect can prevent the progression of irreversible liver dysfunction. |
format | Article |
id | doaj-art-ed48551a57c24427b84c9011a9e40f69 |
institution | Kabale University |
issn | 0962-9351 1466-1861 |
language | English |
publishDate | 2018-01-01 |
publisher | Wiley |
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series | Mediators of Inflammation |
spelling | doaj-art-ed48551a57c24427b84c9011a9e40f692025-02-03T00:59:15ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/54917975491797Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity ImagingEun Jung Kyung0Hyun Bum Kim1Eun Sang Hwang2Seok Lee3Bup Kyung Choi4Jin Woong Kim5Hyung Joong Kim6Sang Moo Lim7Oh In Kwon8Eung Je Woo9College of Medicine, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Radiology, Chonnam National University Medical School, Gwangju 61469, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of KoreaDepartment of Mathematics, Konkuk University, Seoul 05029, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaIn oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin’s anti-inflammatory effect can prevent the progression of irreversible liver dysfunction.http://dx.doi.org/10.1155/2018/5491797 |
spellingShingle | Eun Jung Kyung Hyun Bum Kim Eun Sang Hwang Seok Lee Bup Kyung Choi Jin Woong Kim Hyung Joong Kim Sang Moo Lim Oh In Kwon Eung Je Woo Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging Mediators of Inflammation |
title | Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging |
title_full | Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging |
title_fullStr | Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging |
title_full_unstemmed | Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging |
title_short | Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging |
title_sort | evaluation of hepatoprotective effect of curcumin on liver cirrhosis using a combination of biochemical analysis and magnetic resonance based electrical conductivity imaging |
url | http://dx.doi.org/10.1155/2018/5491797 |
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