Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging

In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosam...

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Main Authors: Eun Jung Kyung, Hyun Bum Kim, Eun Sang Hwang, Seok Lee, Bup Kyung Choi, Jin Woong Kim, Hyung Joong Kim, Sang Moo Lim, Oh In Kwon, Eung Je Woo
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2018/5491797
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author Eun Jung Kyung
Hyun Bum Kim
Eun Sang Hwang
Seok Lee
Bup Kyung Choi
Jin Woong Kim
Hyung Joong Kim
Sang Moo Lim
Oh In Kwon
Eung Je Woo
author_facet Eun Jung Kyung
Hyun Bum Kim
Eun Sang Hwang
Seok Lee
Bup Kyung Choi
Jin Woong Kim
Hyung Joong Kim
Sang Moo Lim
Oh In Kwon
Eung Je Woo
author_sort Eun Jung Kyung
collection DOAJ
description In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin’s anti-inflammatory effect can prevent the progression of irreversible liver dysfunction.
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publishDate 2018-01-01
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series Mediators of Inflammation
spelling doaj-art-ed48551a57c24427b84c9011a9e40f692025-02-03T00:59:15ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/54917975491797Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity ImagingEun Jung Kyung0Hyun Bum Kim1Eun Sang Hwang2Seok Lee3Bup Kyung Choi4Jin Woong Kim5Hyung Joong Kim6Sang Moo Lim7Oh In Kwon8Eung Je Woo9College of Medicine, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaDepartment of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Radiology, Chonnam National University Medical School, Gwangju 61469, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of KoreaDepartment of Mathematics, Konkuk University, Seoul 05029, Republic of KoreaImpedance Imaging Research Center (IIRC), Kyung Hee University, Seoul 02447, Republic of KoreaIn oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin’s anti-inflammatory effect can prevent the progression of irreversible liver dysfunction.http://dx.doi.org/10.1155/2018/5491797
spellingShingle Eun Jung Kyung
Hyun Bum Kim
Eun Sang Hwang
Seok Lee
Bup Kyung Choi
Jin Woong Kim
Hyung Joong Kim
Sang Moo Lim
Oh In Kwon
Eung Je Woo
Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
Mediators of Inflammation
title Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
title_full Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
title_fullStr Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
title_full_unstemmed Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
title_short Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging
title_sort evaluation of hepatoprotective effect of curcumin on liver cirrhosis using a combination of biochemical analysis and magnetic resonance based electrical conductivity imaging
url http://dx.doi.org/10.1155/2018/5491797
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