Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review

<i>Candida</i> infective endocarditis presents therapeutic challenges with high mortality. A complex case of <i>Candida</i> prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with...

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Main Authors: Ricardo El Nouwar, Eva Larranaga Lapique, Frédéric Vanden Eynden, Delphine Martiny, Myriam Remmelink, Ana Roussoulières, Maya Hites
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Microorganisms
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Online Access:https://www.mdpi.com/2076-2607/13/3/580
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author Ricardo El Nouwar
Eva Larranaga Lapique
Frédéric Vanden Eynden
Delphine Martiny
Myriam Remmelink
Ana Roussoulières
Maya Hites
author_facet Ricardo El Nouwar
Eva Larranaga Lapique
Frédéric Vanden Eynden
Delphine Martiny
Myriam Remmelink
Ana Roussoulières
Maya Hites
author_sort Ricardo El Nouwar
collection DOAJ
description <i>Candida</i> infective endocarditis presents therapeutic challenges with high mortality. A complex case of <i>Candida</i> prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with heart transplantation. The literature review revealed a few cases of bacterial endocarditis successfully treated with heart transplantation, but with only two transplanted cases of fungal endocarditis. This report explores heart transplantation as a last resort for managing refractory infective endocarditis. The patient is still alive and free of infection, two and a half years after transplantation.
format Article
id doaj-art-ed42d77b22e14a2da7173ce0c5dcdf47
institution Kabale University
issn 2076-2607
language English
publishDate 2025-03-01
publisher MDPI AG
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series Microorganisms
spelling doaj-art-ed42d77b22e14a2da7173ce0c5dcdf472025-08-20T03:43:10ZengMDPI AGMicroorganisms2076-26072025-03-0113358010.3390/microorganisms13030580Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature ReviewRicardo El Nouwar0Eva Larranaga Lapique1Frédéric Vanden Eynden2Delphine Martiny3Myriam Remmelink4Ana Roussoulières5Maya Hites6Clinic of Infectious Diseases, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumClinic of Infectious Diseases, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Cardiac Surgery, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumLaboratoire Hospitalier Universitaire de Bruxelles-Université Libre de Bruxelles (LHUB-ULB), 1000 Brussels, BelgiumAnatomy and Pathology Department, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumDepartment of Cardiology, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, BelgiumClinic of Infectious Diseases, Hôpital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium<i>Candida</i> infective endocarditis presents therapeutic challenges with high mortality. A complex case of <i>Candida</i> prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with heart transplantation. The literature review revealed a few cases of bacterial endocarditis successfully treated with heart transplantation, but with only two transplanted cases of fungal endocarditis. This report explores heart transplantation as a last resort for managing refractory infective endocarditis. The patient is still alive and free of infection, two and a half years after transplantation.https://www.mdpi.com/2076-2607/13/3/580fungal endocarditisheart transplantationantifungal therapy<i>Candida</i> infection
spellingShingle Ricardo El Nouwar
Eva Larranaga Lapique
Frédéric Vanden Eynden
Delphine Martiny
Myriam Remmelink
Ana Roussoulières
Maya Hites
Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
Microorganisms
fungal endocarditis
heart transplantation
antifungal therapy
<i>Candida</i> infection
title Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
title_full Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
title_fullStr Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
title_full_unstemmed Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
title_short Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
title_sort case report heart transplantation for refractory i candida tropicalis i endocarditis a case report and literature review
topic fungal endocarditis
heart transplantation
antifungal therapy
<i>Candida</i> infection
url https://www.mdpi.com/2076-2607/13/3/580
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