Case Report: Heart Transplantation for Refractory <i>Candida tropicalis</i> Endocarditis: A Case Report and Literature Review
<i>Candida</i> infective endocarditis presents therapeutic challenges with high mortality. A complex case of <i>Candida</i> prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/3/580 |
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| Summary: | <i>Candida</i> infective endocarditis presents therapeutic challenges with high mortality. A complex case of <i>Candida</i> prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with heart transplantation. The literature review revealed a few cases of bacterial endocarditis successfully treated with heart transplantation, but with only two transplanted cases of fungal endocarditis. This report explores heart transplantation as a last resort for managing refractory infective endocarditis. The patient is still alive and free of infection, two and a half years after transplantation. |
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| ISSN: | 2076-2607 |