The emerging role of targeting cancer metabolism for cancer therapy
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic gly...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-10-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428320965284 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849686411040522240 |
|---|---|
| author | Pegah Farhadi Reza Yarani Sadat Dokaneheifard Kamran Mansouri |
| author_facet | Pegah Farhadi Reza Yarani Sadat Dokaneheifard Kamran Mansouri |
| author_sort | Pegah Farhadi |
| collection | DOAJ |
| description | Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic glycolysis and other cancer-specific metabolism changes are known as the cancer hallmarks, distinct cancer cells from normal cells. Therefore, these tumor-specific characteristics receive the limelight as targets for cancer therapy. Glutamine, serine, and fatty acid oxidation together with 5-lipoxygenase are main pathways that have attracted lots of attention for cancer therapy. In this review, we not only discuss different tumor metabolism aspects but also discuss the metabolism roles in the promotion of cancer cells at different stages and their difference with normal cells. Besides, we dissect the inhibitors potential in blocking the main metabolic pathways to introduce the effective and non-effective inhibitors in the field. |
| format | Article |
| id | doaj-art-ed4298b87bf34f069d324391b14620d5 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-ed4298b87bf34f069d324391b14620d52025-08-20T03:22:42ZengSAGE PublishingTumor Biology1423-03802020-10-014210.1177/1010428320965284The emerging role of targeting cancer metabolism for cancer therapyPegah Farhadi0Reza Yarani1Sadat Dokaneheifard2Kamran Mansouri3Medical Biology Research Center, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranTranslational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, DenmarkSylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Molecular Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranGlucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic glycolysis and other cancer-specific metabolism changes are known as the cancer hallmarks, distinct cancer cells from normal cells. Therefore, these tumor-specific characteristics receive the limelight as targets for cancer therapy. Glutamine, serine, and fatty acid oxidation together with 5-lipoxygenase are main pathways that have attracted lots of attention for cancer therapy. In this review, we not only discuss different tumor metabolism aspects but also discuss the metabolism roles in the promotion of cancer cells at different stages and their difference with normal cells. Besides, we dissect the inhibitors potential in blocking the main metabolic pathways to introduce the effective and non-effective inhibitors in the field.https://doi.org/10.1177/1010428320965284 |
| spellingShingle | Pegah Farhadi Reza Yarani Sadat Dokaneheifard Kamran Mansouri The emerging role of targeting cancer metabolism for cancer therapy Tumor Biology |
| title | The emerging role of targeting cancer metabolism for cancer therapy |
| title_full | The emerging role of targeting cancer metabolism for cancer therapy |
| title_fullStr | The emerging role of targeting cancer metabolism for cancer therapy |
| title_full_unstemmed | The emerging role of targeting cancer metabolism for cancer therapy |
| title_short | The emerging role of targeting cancer metabolism for cancer therapy |
| title_sort | emerging role of targeting cancer metabolism for cancer therapy |
| url | https://doi.org/10.1177/1010428320965284 |
| work_keys_str_mv | AT pegahfarhadi theemergingroleoftargetingcancermetabolismforcancertherapy AT rezayarani theemergingroleoftargetingcancermetabolismforcancertherapy AT sadatdokaneheifard theemergingroleoftargetingcancermetabolismforcancertherapy AT kamranmansouri theemergingroleoftargetingcancermetabolismforcancertherapy AT pegahfarhadi emergingroleoftargetingcancermetabolismforcancertherapy AT rezayarani emergingroleoftargetingcancermetabolismforcancertherapy AT sadatdokaneheifard emergingroleoftargetingcancermetabolismforcancertherapy AT kamranmansouri emergingroleoftargetingcancermetabolismforcancertherapy |