Reduced butyrate-producing bacteria and altered metabolic pathways in the gut microbiome of immunoglobulin A nephropathy patients

Reduced butyrate-producing bacteria and altered metabolic pathways in the gut microbiome of immunoglobulin A nephropathy patients

Abstract Gut-associated lymphoid tissue is central to the production of galactose-deficient IgA1 (Gd-IgA1), a key factor in immunoglobulin A nephropathy (IgAN). Although no major differences in gut microbiome diversity have been reported across IgAN cohorts, functional alterations in microbial compo...

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Main Authors: Anna Popova, Kārlis Rācenis, Monta Brīvība, Rihards Saksis, Mikus Saulīte, Baiba Šlisere, Egija Berga-Švītiņa, Kristīne Oļeiņika, Anna Jana Saulīte, Jānis Seilis, Juta Kroiča, Harijs Čerņevskis, Aivars Pētersons, Jānis Kloviņš, Aivars Lejnieks, Viktorija Kuzema
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Gut microbiome
Immunoglobulin a nephropathy
Progressors
Butyrate-producing bacteria
Online Access:https://doi.org/10.1038/s41598-025-13629-5
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