Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease
Summary: Altered gut microbiota‒metabolite interactions may result in intestinal inflammation severity variation in Crohn’s disease (CD). Magnetic resonance enterography (MRE) advances anti-inflammatory strategy development. We aimed to identify inflammation-related multiomics factors and MRE intera...
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Elsevier
2025-05-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225005711 |
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| author | Ruonan Zhang Zhoulei Li Li Huang Weimiao Kong Yidong Zheng Yangdi Wang Xiaodi Shen Lili Huang Xinyue Wang Qingzhu Zheng Luyao Wu Yaoqi Ke Ren Mao Zhenpeng Peng Canhui Sun Shi-Ting Feng Shaochun Lin Yejun Wang Xuehua Li |
| author_facet | Ruonan Zhang Zhoulei Li Li Huang Weimiao Kong Yidong Zheng Yangdi Wang Xiaodi Shen Lili Huang Xinyue Wang Qingzhu Zheng Luyao Wu Yaoqi Ke Ren Mao Zhenpeng Peng Canhui Sun Shi-Ting Feng Shaochun Lin Yejun Wang Xuehua Li |
| author_sort | Ruonan Zhang |
| collection | DOAJ |
| description | Summary: Altered gut microbiota‒metabolite interactions may result in intestinal inflammation severity variation in Crohn’s disease (CD). Magnetic resonance enterography (MRE) advances anti-inflammatory strategy development. We aimed to identify inflammation-related multiomics factors and MRE interactions for CD management, analyzing 425 CD patients and 42 healthy controls undergoing MRE, ileocolonoscopy, and fecal/blood sampling (microbiota/metabolite analyses), with intestinal inflammation categorized by MRE and ileocolonoscopy. Ruminococcus species were enriched in CD patients versus healthy controls, while Pseudomonas and Staphylococcus dominated moderate–severe versus no–mild inflammation groups, suggesting inflammation-level associations. Ruminococcus gauvreauii suppressed intestinal inflammation by regulating serum PC(O-34:3), ePE(38:6), and ceramides (all p < 0.05). Serum N-acetylneuraminic acid and guanidinoacetic acid correlated with intestinal morphological changes (e.g., MRE-detectable effusion and wall thickness) and inflammation severity (PACME < 0.05). A link was established between microscopic microbiota-metabolite markers and macroscopic imaging of inflammatory features, which could offer valuable insights into inflammation management. |
| format | Article |
| id | doaj-art-ed3d2f344d8444d28a58e5351eee821b |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-ed3d2f344d8444d28a58e5351eee821b2025-08-20T03:18:19ZengElsevieriScience2589-00422025-05-0128511231010.1016/j.isci.2025.112310Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s diseaseRuonan Zhang0Zhoulei Li1Li Huang2Weimiao Kong3Yidong Zheng4Yangdi Wang5Xiaodi Shen6Lili Huang7Xinyue Wang8Qingzhu Zheng9Luyao Wu10Yaoqi Ke11Ren Mao12Zhenpeng Peng13Canhui Sun14Shi-Ting Feng15Shaochun Lin16Yejun Wang17Xuehua Li18Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaYouth Innovation Team of Medical Bioinformatics, Shenzhen University Medical School, Shenzhen 518060, China; Department of Cell Biology and Genetics, College of Basic Medicine, Shenzhen University Medical School, Shenzhen 518060, ChinaYouth Innovation Team of Medical Bioinformatics, Shenzhen University Medical School, Shenzhen 518060, China; Department of Cell Biology and Genetics, College of Basic Medicine, Shenzhen University Medical School, Shenzhen 518060, ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, P.R. ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of China; Corresponding authorDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, P.R. China; Corresponding authorDepartment of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou 510080, People's Republic of China; Corresponding authorSummary: Altered gut microbiota‒metabolite interactions may result in intestinal inflammation severity variation in Crohn’s disease (CD). Magnetic resonance enterography (MRE) advances anti-inflammatory strategy development. We aimed to identify inflammation-related multiomics factors and MRE interactions for CD management, analyzing 425 CD patients and 42 healthy controls undergoing MRE, ileocolonoscopy, and fecal/blood sampling (microbiota/metabolite analyses), with intestinal inflammation categorized by MRE and ileocolonoscopy. Ruminococcus species were enriched in CD patients versus healthy controls, while Pseudomonas and Staphylococcus dominated moderate–severe versus no–mild inflammation groups, suggesting inflammation-level associations. Ruminococcus gauvreauii suppressed intestinal inflammation by regulating serum PC(O-34:3), ePE(38:6), and ceramides (all p < 0.05). Serum N-acetylneuraminic acid and guanidinoacetic acid correlated with intestinal morphological changes (e.g., MRE-detectable effusion and wall thickness) and inflammation severity (PACME < 0.05). A link was established between microscopic microbiota-metabolite markers and macroscopic imaging of inflammatory features, which could offer valuable insights into inflammation management.http://www.sciencedirect.com/science/article/pii/S2589004225005711MicrobiologyBioinformaticsOmics |
| spellingShingle | Ruonan Zhang Zhoulei Li Li Huang Weimiao Kong Yidong Zheng Yangdi Wang Xiaodi Shen Lili Huang Xinyue Wang Qingzhu Zheng Luyao Wu Yaoqi Ke Ren Mao Zhenpeng Peng Canhui Sun Shi-Ting Feng Shaochun Lin Yejun Wang Xuehua Li Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease iScience Microbiology Bioinformatics Omics |
| title | Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease |
| title_full | Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease |
| title_fullStr | Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease |
| title_full_unstemmed | Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease |
| title_short | Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease |
| title_sort | altered gut microbiome metabolite interactions link intestinal inflammation severity and mr enterography abnormalities in crohn s disease |
| topic | Microbiology Bioinformatics Omics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225005711 |
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