Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease

Altered gut microbiome-metabolite interactions link intestinal inflammation severity and MR enterography abnormalities in Crohn’s disease

Summary: Altered gut microbiota‒metabolite interactions may result in intestinal inflammation severity variation in Crohn’s disease (CD). Magnetic resonance enterography (MRE) advances anti-inflammatory strategy development. We aimed to identify inflammation-related multiomics factors and MRE intera...

Full description

Saved in:
Bibliographic Details
Main Authors: Ruonan Zhang, Zhoulei Li, Li Huang, Weimiao Kong, Yidong Zheng, Yangdi Wang, Xiaodi Shen, Lili Huang, Xinyue Wang, Qingzhu Zheng, Luyao Wu, Yaoqi Ke, Ren Mao, Zhenpeng Peng, Canhui Sun, Shi-Ting Feng, Shaochun Lin, Yejun Wang, Xuehua Li
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Microbiology
Bioinformatics
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005711
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary: Altered gut microbiota‒metabolite interactions may result in intestinal inflammation severity variation in Crohn’s disease (CD). Magnetic resonance enterography (MRE) advances anti-inflammatory strategy development. We aimed to identify inflammation-related multiomics factors and MRE interactions for CD management, analyzing 425 CD patients and 42 healthy controls undergoing MRE, ileocolonoscopy, and fecal/blood sampling (microbiota/metabolite analyses), with intestinal inflammation categorized by MRE and ileocolonoscopy. Ruminococcus species were enriched in CD patients versus healthy controls, while Pseudomonas and Staphylococcus dominated moderate–severe versus no–mild inflammation groups, suggesting inflammation-level associations. Ruminococcus gauvreauii suppressed intestinal inflammation by regulating serum PC(O-34:3), ePE(38:6), and ceramides (all p < 0.05). Serum N-acetylneuraminic acid and guanidinoacetic acid correlated with intestinal morphological changes (e.g., MRE-detectable effusion and wall thickness) and inflammation severity (PACME < 0.05). A link was established between microscopic microbiota-metabolite markers and macroscopic imaging of inflammatory features, which could offer valuable insights into inflammation management.
ISSN:2589-0042

Similar Items