The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae
Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in healthy human gut and the relationship betwee...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2114739 |
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| author | Jing Yang Yi Li Na Tang Juan Li Juan Zhou Shan Lu Gui Zhang Yuqin Song Chao Wang Jin Zhong Jianguo Xu Jie Feng |
| author_facet | Jing Yang Yi Li Na Tang Juan Li Juan Zhou Shan Lu Gui Zhang Yuqin Song Chao Wang Jin Zhong Jianguo Xu Jie Feng |
| author_sort | Jing Yang |
| collection | DOAJ |
| description | Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in healthy human gut and the relationship between gut hvKp and clinically important invasive strains. We compile global genomes of gut K. pneumoniae for in-depth genetic analysis and found most hvKp genomes originated from Chinese datasets; therefore, we collected gut K. pneumoniae isolates from healthy people around China. The results revealed a moderate carriage rate of hvKp in the healthy population (4%–5.19%). Phylogenetic analysis indicated a close relationship between gut hvKp and fatal clinical strains. These results demonstrate that the human gut may serve as a reservoir of hvKp and that gut hvKp can play a role in infection of other body parts. |
| format | Article |
| id | doaj-art-ed3aa6dacfdb4698ae4a1cff20e8e1c3 |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-ed3aa6dacfdb4698ae4a1cff20e8e1c32025-08-20T03:05:25ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2114739The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniaeJing Yang0Yi Li1Na Tang2Juan Li3Juan Zhou4Shan Lu5Gui Zhang6Yuqin Song7Chao Wang8Jin Zhong9Jianguo Xu10Jie Feng11State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaHypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in healthy human gut and the relationship between gut hvKp and clinically important invasive strains. We compile global genomes of gut K. pneumoniae for in-depth genetic analysis and found most hvKp genomes originated from Chinese datasets; therefore, we collected gut K. pneumoniae isolates from healthy people around China. The results revealed a moderate carriage rate of hvKp in the healthy population (4%–5.19%). Phylogenetic analysis indicated a close relationship between gut hvKp and fatal clinical strains. These results demonstrate that the human gut may serve as a reservoir of hvKp and that gut hvKp can play a role in infection of other body parts.https://www.tandfonline.com/doi/10.1080/19490976.2022.2114739Hypervirulent Klebsiella pneumoniaehealthy peoplehuman gutreservoir |
| spellingShingle | Jing Yang Yi Li Na Tang Juan Li Juan Zhou Shan Lu Gui Zhang Yuqin Song Chao Wang Jin Zhong Jianguo Xu Jie Feng The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae Gut Microbes Hypervirulent Klebsiella pneumoniae healthy people human gut reservoir |
| title | The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae |
| title_full | The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae |
| title_fullStr | The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae |
| title_full_unstemmed | The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae |
| title_short | The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae |
| title_sort | human gut serves as a reservoir of hypervirulent klebsiella pneumoniae |
| topic | Hypervirulent Klebsiella pneumoniae healthy people human gut reservoir |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2114739 |
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