Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/916585 |
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| _version_ | 1849690810844446720 |
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| author | Anisha A. Gupte Henry J. Pownall Dale J. Hamilton |
| author_facet | Anisha A. Gupte Henry J. Pownall Dale J. Hamilton |
| author_sort | Anisha A. Gupte |
| collection | DOAJ |
| description | Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-α elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate insulin signaling, substrate oxidation, and energetics. This paper reviews clinical and experimental studies on the mechanisms of estrogen and the current state of knowledge regarding physiological and pathobiological influences of estrogen on metabolism. |
| format | Article |
| id | doaj-art-ed395869b8ea4d6f99b583a8fd4355eb |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ed395869b8ea4d6f99b583a8fd4355eb2025-08-20T03:21:12ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/916585916585Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial FunctionAnisha A. Gupte0Henry J. Pownall1Dale J. Hamilton2Bioenergetics Laboratory, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USAAtherosclerosis & Lipoprotein Research, Methodist DeBakey Heart and Vascular Institute, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USABioenergetics Laboratory, Houston Methodist Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USAClinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action. The metabolic effects of estrogen are mediated primarily by its receptor, estrogen receptor-α; however, the detailed understanding of its mechanisms is incomplete. Recent investigations suggest that estrogen receptor-α elicits the metabolic effects of estrogen by genomic, nongenomic, and mitochondrial mechanisms that regulate insulin signaling, substrate oxidation, and energetics. This paper reviews clinical and experimental studies on the mechanisms of estrogen and the current state of knowledge regarding physiological and pathobiological influences of estrogen on metabolism.http://dx.doi.org/10.1155/2015/916585 |
| spellingShingle | Anisha A. Gupte Henry J. Pownall Dale J. Hamilton Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function Journal of Diabetes Research |
| title | Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function |
| title_full | Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function |
| title_fullStr | Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function |
| title_full_unstemmed | Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function |
| title_short | Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function |
| title_sort | estrogen an emerging regulator of insulin action and mitochondrial function |
| url | http://dx.doi.org/10.1155/2015/916585 |
| work_keys_str_mv | AT anishaagupte estrogenanemergingregulatorofinsulinactionandmitochondrialfunction AT henryjpownall estrogenanemergingregulatorofinsulinactionandmitochondrialfunction AT dalejhamilton estrogenanemergingregulatorofinsulinactionandmitochondrialfunction |