Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy
Abstract Electroencephalography (EEG) and optical neuromonitoring were used to predict short-term outcomes in neonates undergoing therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Fifty-two neonates undergoing TH for HIE were prospectively recruited. Continuous EEG monitoring w...
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Nature Portfolio
2025-06-01
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| author | Rasheda Arman Chowdhury Zamzam Mahdi Beatrice Desnous Bohdana Marandyuk Ala Birca Ramy El-Jalbout Anne-Monique Nuyt Elana F. Pinchefsky Mathieu Dehaes |
| author_facet | Rasheda Arman Chowdhury Zamzam Mahdi Beatrice Desnous Bohdana Marandyuk Ala Birca Ramy El-Jalbout Anne-Monique Nuyt Elana F. Pinchefsky Mathieu Dehaes |
| author_sort | Rasheda Arman Chowdhury |
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| description | Abstract Electroencephalography (EEG) and optical neuromonitoring were used to predict short-term outcomes in neonates undergoing therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Fifty-two neonates undergoing TH for HIE were prospectively recruited. Continuous EEG monitoring was initiated within 24 h of life and a quantitative discontinuity index was calculated. Combined frequency-domain near infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) were initiated within 48 h of life and used to measure cerebral hemoglobin oxygen saturation (SO2) and a cerebral blood flow index. Using these parameters and hemoglobin concentration measurements, cerebral oxygen extraction fraction (OEF), indices of cerebral oxygen delivery and metabolism (CMRO2i) as well as cerebral oxygen reserve (CRO2) were derived. Short-term outcome was classified based on brain injury pattern on magnetic resonance imaging and/or death; as normal-mild, moderate or severe outcome. Results showed that EEG discontinuity index, SO2 and CRO2 were higher and OEF lower in neonates with severe compared to normal-mild and moderate outcomes during TH. EEG discontinuity index was the most accurate and earliest parameter to identify moderate vs. severe outcomes while CMRO2i identified normal-mild vs. moderate outcomes as early as day 2 of TH. Combining EEG and FDNIRS-DCS parameters improved area-under-the-curve, sensitivity and specificity for most of the predictive models. |
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| spelling | doaj-art-ed3253d37bf345b5a96f87d0d8e684cf2025-08-20T02:05:13ZengNature PortfolioScientific Reports2045-23222025-06-0115111310.1038/s41598-025-04271-2Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathyRasheda Arman Chowdhury0Zamzam Mahdi1Beatrice Desnous2Bohdana Marandyuk3Ala Birca4Ramy El-Jalbout5Anne-Monique Nuyt6Elana F. Pinchefsky7Mathieu Dehaes8Research Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreResearch Center, CHU Sainte-Justine University Hospital CentreAbstract Electroencephalography (EEG) and optical neuromonitoring were used to predict short-term outcomes in neonates undergoing therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Fifty-two neonates undergoing TH for HIE were prospectively recruited. Continuous EEG monitoring was initiated within 24 h of life and a quantitative discontinuity index was calculated. Combined frequency-domain near infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) were initiated within 48 h of life and used to measure cerebral hemoglobin oxygen saturation (SO2) and a cerebral blood flow index. Using these parameters and hemoglobin concentration measurements, cerebral oxygen extraction fraction (OEF), indices of cerebral oxygen delivery and metabolism (CMRO2i) as well as cerebral oxygen reserve (CRO2) were derived. Short-term outcome was classified based on brain injury pattern on magnetic resonance imaging and/or death; as normal-mild, moderate or severe outcome. Results showed that EEG discontinuity index, SO2 and CRO2 were higher and OEF lower in neonates with severe compared to normal-mild and moderate outcomes during TH. EEG discontinuity index was the most accurate and earliest parameter to identify moderate vs. severe outcomes while CMRO2i identified normal-mild vs. moderate outcomes as early as day 2 of TH. Combining EEG and FDNIRS-DCS parameters improved area-under-the-curve, sensitivity and specificity for most of the predictive models.https://doi.org/10.1038/s41598-025-04271-2Hypoxic-ischemic encephalopathy (HIE)Electroencephalography (EEG)Frequency-domain near infrared spectroscopy (FDNIRS)Diffuse correlation spectroscopy (DCS)Magnetic resonance imaging (MRI)Predictive models |
| spellingShingle | Rasheda Arman Chowdhury Zamzam Mahdi Beatrice Desnous Bohdana Marandyuk Ala Birca Ramy El-Jalbout Anne-Monique Nuyt Elana F. Pinchefsky Mathieu Dehaes Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy Scientific Reports Hypoxic-ischemic encephalopathy (HIE) Electroencephalography (EEG) Frequency-domain near infrared spectroscopy (FDNIRS) Diffuse correlation spectroscopy (DCS) Magnetic resonance imaging (MRI) Predictive models |
| title | Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy |
| title_full | Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy |
| title_fullStr | Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy |
| title_full_unstemmed | Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy |
| title_short | Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy |
| title_sort | electroencephalography and optical neuromonitoring predict short term outcomes in neonates undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy |
| topic | Hypoxic-ischemic encephalopathy (HIE) Electroencephalography (EEG) Frequency-domain near infrared spectroscopy (FDNIRS) Diffuse correlation spectroscopy (DCS) Magnetic resonance imaging (MRI) Predictive models |
| url | https://doi.org/10.1038/s41598-025-04271-2 |
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