Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
Background The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e087954.full |
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| author | Yan He Jiajia Jiang Zhang Xia Guozheng Xu Mingyang Zhao Peiyu Ye Xiaoqing Ma Jinmei Zhang Jiale Zhong Sen Qiao Shulong Shi |
| author_facet | Yan He Jiajia Jiang Zhang Xia Guozheng Xu Mingyang Zhao Peiyu Ye Xiaoqing Ma Jinmei Zhang Jiale Zhong Sen Qiao Shulong Shi |
| author_sort | Yan He |
| collection | DOAJ |
| description | Background The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.Research design and methods This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records. Multivariate logistic regression analysis was performed to assess the association between hyperuricaemia and dyslipidaemia. Restricted cubic splines (RCS) analysis was performed to determine the optimal SUA level for the lower risk of dyslipidaemia.Results After adjustment for the potential confounders, hyperuricaemia was significantly associated with dyslipidaemia (OR=3.72, 95% CI: 2.28, 6.07) and hypertriglyceridaemia (OR=2.63, 95% CI: 1.68, 4.12). Notably, mediation analysis revealed a significant mediating effect of SUA in this relationship (indirect effect=0.08, p<0.001), elucidating 20.1% of the total relationship.Conclusions Hyperuricaemia was positively associated with dyslipidaemia and hypertriglyceridaemia. SUA mediated the effect of insulin resistance on triglyceride metabolism in patients with T2DM. A potential benefit of stricter control of SUA levels among patients with T2DM is possibly reducing the risk of dyslipidaemia. |
| format | Article |
| id | doaj-art-ed323dbc2e4c4f938e92c4985725c6dd |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ed323dbc2e4c4f938e92c4985725c6dd2025-01-31T00:25:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-087954Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional studyYan He0Jiajia Jiang1Zhang Xia2Guozheng Xu3Mingyang Zhao4Peiyu Ye5Xiaoqing Ma6Jinmei Zhang7Jiale Zhong8Sen Qiao9Shulong Shi10Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaPostdoctoral of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Epidemiology and Biostatistics, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Endocrinology, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Weifang Traditional Chinese Hospital, Weifang, Shandong, ChinaDepartment of Public Service Management, School of Management, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Hepatological Surgery, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaBackground The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.Research design and methods This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records. Multivariate logistic regression analysis was performed to assess the association between hyperuricaemia and dyslipidaemia. Restricted cubic splines (RCS) analysis was performed to determine the optimal SUA level for the lower risk of dyslipidaemia.Results After adjustment for the potential confounders, hyperuricaemia was significantly associated with dyslipidaemia (OR=3.72, 95% CI: 2.28, 6.07) and hypertriglyceridaemia (OR=2.63, 95% CI: 1.68, 4.12). Notably, mediation analysis revealed a significant mediating effect of SUA in this relationship (indirect effect=0.08, p<0.001), elucidating 20.1% of the total relationship.Conclusions Hyperuricaemia was positively associated with dyslipidaemia and hypertriglyceridaemia. SUA mediated the effect of insulin resistance on triglyceride metabolism in patients with T2DM. A potential benefit of stricter control of SUA levels among patients with T2DM is possibly reducing the risk of dyslipidaemia.https://bmjopen.bmj.com/content/15/1/e087954.full |
| spellingShingle | Yan He Jiajia Jiang Zhang Xia Guozheng Xu Mingyang Zhao Peiyu Ye Xiaoqing Ma Jinmei Zhang Jiale Zhong Sen Qiao Shulong Shi Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study BMJ Open |
| title | Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study |
| title_full | Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study |
| title_fullStr | Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study |
| title_full_unstemmed | Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study |
| title_short | Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study |
| title_sort | association between serum uric acid and dyslipidaemia in type 2 diabetes a cross sectional study |
| url | https://bmjopen.bmj.com/content/15/1/e087954.full |
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