Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study

Background The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk...

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Main Authors: Yan He, Jiajia Jiang, Zhang Xia, Guozheng Xu, Mingyang Zhao, Peiyu Ye, Xiaoqing Ma, Jinmei Zhang, Jiale Zhong, Sen Qiao, Shulong Shi
Format: Article
Language:English
Published: BMJ Publishing Group 2025-01-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/1/e087954.full
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author Yan He
Jiajia Jiang
Zhang Xia
Guozheng Xu
Mingyang Zhao
Peiyu Ye
Xiaoqing Ma
Jinmei Zhang
Jiale Zhong
Sen Qiao
Shulong Shi
author_facet Yan He
Jiajia Jiang
Zhang Xia
Guozheng Xu
Mingyang Zhao
Peiyu Ye
Xiaoqing Ma
Jinmei Zhang
Jiale Zhong
Sen Qiao
Shulong Shi
author_sort Yan He
collection DOAJ
description Background The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.Research design and methods This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records. Multivariate logistic regression analysis was performed to assess the association between hyperuricaemia and dyslipidaemia. Restricted cubic splines (RCS) analysis was performed to determine the optimal SUA level for the lower risk of dyslipidaemia.Results After adjustment for the potential confounders, hyperuricaemia was significantly associated with dyslipidaemia (OR=3.72, 95% CI: 2.28, 6.07) and hypertriglyceridaemia (OR=2.63, 95% CI: 1.68, 4.12). Notably, mediation analysis revealed a significant mediating effect of SUA in this relationship (indirect effect=0.08, p<0.001), elucidating 20.1% of the total relationship.Conclusions Hyperuricaemia was positively associated with dyslipidaemia and hypertriglyceridaemia. SUA mediated the effect of insulin resistance on triglyceride metabolism in patients with T2DM. A potential benefit of stricter control of SUA levels among patients with T2DM is possibly reducing the risk of dyslipidaemia.
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spelling doaj-art-ed323dbc2e4c4f938e92c4985725c6dd2025-01-31T00:25:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-087954Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional studyYan He0Jiajia Jiang1Zhang Xia2Guozheng Xu3Mingyang Zhao4Peiyu Ye5Xiaoqing Ma6Jinmei Zhang7Jiale Zhong8Sen Qiao9Shulong Shi10Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaPostdoctoral of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Epidemiology and Biostatistics, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Endocrinology, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Weifang Traditional Chinese Hospital, Weifang, Shandong, ChinaDepartment of Public Service Management, School of Management, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Hepatological Surgery, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, Shandong, ChinaBackground The association between serum uric acid (SUA) and dyslipidaemia is still unclear in patients with type 2 diabetes mellitus (T2DM). This study aimed to examine the association between SUA and dyslipidaemia and to explore whether there is an optimal SUA level corresponding to the lower risk of suffering from dyslipidaemia.Research design and methods This cross-sectional study included 1036 inpatients with T2DM and the clinical data were extracted from the hospital medical records. Multivariate logistic regression analysis was performed to assess the association between hyperuricaemia and dyslipidaemia. Restricted cubic splines (RCS) analysis was performed to determine the optimal SUA level for the lower risk of dyslipidaemia.Results After adjustment for the potential confounders, hyperuricaemia was significantly associated with dyslipidaemia (OR=3.72, 95% CI: 2.28, 6.07) and hypertriglyceridaemia (OR=2.63, 95% CI: 1.68, 4.12). Notably, mediation analysis revealed a significant mediating effect of SUA in this relationship (indirect effect=0.08, p<0.001), elucidating 20.1% of the total relationship.Conclusions Hyperuricaemia was positively associated with dyslipidaemia and hypertriglyceridaemia. SUA mediated the effect of insulin resistance on triglyceride metabolism in patients with T2DM. A potential benefit of stricter control of SUA levels among patients with T2DM is possibly reducing the risk of dyslipidaemia.https://bmjopen.bmj.com/content/15/1/e087954.full
spellingShingle Yan He
Jiajia Jiang
Zhang Xia
Guozheng Xu
Mingyang Zhao
Peiyu Ye
Xiaoqing Ma
Jinmei Zhang
Jiale Zhong
Sen Qiao
Shulong Shi
Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
BMJ Open
title Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
title_full Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
title_fullStr Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
title_full_unstemmed Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
title_short Association between serum uric acid and dyslipidaemia in type 2 diabetes: a cross-sectional study
title_sort association between serum uric acid and dyslipidaemia in type 2 diabetes a cross sectional study
url https://bmjopen.bmj.com/content/15/1/e087954.full
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