Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection
Menstrual blood-derived mesenchymal stromal cells (MenSCs) have emerged as a novel source for regenerative medicine, offering a unique alternative to traditional stem cell types, including adipose-derived and bone marrow-derived mesenchymal stromal cells. MenSCs are characterized by their pluripoten...
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| Format: | Article |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1643408/full |
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| author | Raminta Vaiciuleviciute Jolita Pachaleva Eiva Bernotiene Eiva Bernotiene Gabija Kugaudaite Ignas Lebedis Edvinas Krugly Ilona Uzieliene Ilona Uzieliene |
| author_facet | Raminta Vaiciuleviciute Jolita Pachaleva Eiva Bernotiene Eiva Bernotiene Gabija Kugaudaite Ignas Lebedis Edvinas Krugly Ilona Uzieliene Ilona Uzieliene |
| author_sort | Raminta Vaiciuleviciute |
| collection | DOAJ |
| description | Menstrual blood-derived mesenchymal stromal cells (MenSCs) have emerged as a novel source for regenerative medicine, offering a unique alternative to traditional stem cell types, including adipose-derived and bone marrow-derived mesenchymal stromal cells. MenSCs are characterized by their pluripotency, multi-lineage differentiation potential and immunomodulatory properties, which enable them to contribute to the regeneration of various tissues such as skin, uterus, muscle, connective tissues and nerves. Extracellular vesicles (EVs) secreted by MenSCs contain biologically active molecules, including proteins, lipids, and miRNAs, which play a key role in mediating these regenerative effects. Compared to other MSC-derived EVs, MenSC-EVs offer distinct advantages due to their enhanced regenerative capabilities and lower immunogenicity. Moreover, MenSC-EVs are a promising source for disease biomarkers in various diseases, including female reproductive system issues such as infertility. This manuscript reviews the latest findings on MenSCs and their EVs, highlighting their cargo composition, regenerative potential and as a source of biomarkers across multiple tissues, comparing their cargo profiles with EVs derived from other MSC sources. |
| format | Article |
| id | doaj-art-ed2ffac6f8774a169dfdcff0914efa99 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-ed2ffac6f8774a169dfdcff0914efa992025-08-20T03:40:52ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-08-011310.3389/fbioe.2025.16434081643408Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detectionRaminta Vaiciuleviciute0Jolita Pachaleva1Eiva Bernotiene2Eiva Bernotiene3Gabija Kugaudaite4Ignas Lebedis5Edvinas Krugly6Ilona Uzieliene7Ilona Uzieliene8Department of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Chemistry and Bioengineering, VilniusTech Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Vilnius, LithuaniaDepartment of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Environmental Technology, Kaunas University of Technology, Kaunas, LithuaniaDepartment of Regenerative Medicine, Innovative Medicine Centre, Vilnius, LithuaniaDepartment of Environmental Technology, Kaunas University of Technology, Kaunas, LithuaniaMenstrual blood-derived mesenchymal stromal cells (MenSCs) have emerged as a novel source for regenerative medicine, offering a unique alternative to traditional stem cell types, including adipose-derived and bone marrow-derived mesenchymal stromal cells. MenSCs are characterized by their pluripotency, multi-lineage differentiation potential and immunomodulatory properties, which enable them to contribute to the regeneration of various tissues such as skin, uterus, muscle, connective tissues and nerves. Extracellular vesicles (EVs) secreted by MenSCs contain biologically active molecules, including proteins, lipids, and miRNAs, which play a key role in mediating these regenerative effects. Compared to other MSC-derived EVs, MenSC-EVs offer distinct advantages due to their enhanced regenerative capabilities and lower immunogenicity. Moreover, MenSC-EVs are a promising source for disease biomarkers in various diseases, including female reproductive system issues such as infertility. This manuscript reviews the latest findings on MenSCs and their EVs, highlighting their cargo composition, regenerative potential and as a source of biomarkers across multiple tissues, comparing their cargo profiles with EVs derived from other MSC sources.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1643408/fullmenstrual blood mesenchymal stromal cellsextracellular vesiclesMSCsbiomarkerstherapydiagnostics |
| spellingShingle | Raminta Vaiciuleviciute Jolita Pachaleva Eiva Bernotiene Eiva Bernotiene Gabija Kugaudaite Ignas Lebedis Edvinas Krugly Ilona Uzieliene Ilona Uzieliene Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection Frontiers in Bioengineering and Biotechnology menstrual blood mesenchymal stromal cells extracellular vesicles MSCs biomarkers therapy diagnostics |
| title | Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection |
| title_full | Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection |
| title_fullStr | Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection |
| title_full_unstemmed | Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection |
| title_short | Menstrual blood-derived mesenchymal stromal cell extracellular vesicles – a potential tool for tissue regeneration and disease detection |
| title_sort | menstrual blood derived mesenchymal stromal cell extracellular vesicles a potential tool for tissue regeneration and disease detection |
| topic | menstrual blood mesenchymal stromal cells extracellular vesicles MSCs biomarkers therapy diagnostics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1643408/full |
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