All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair
Non-compressible hemorrhage poses a severe threat to life globally, yet achieving effective hemostasis and facilitating tissue repair remain a significant challenge and desired requirement. Herein, the all-in-one extracellular matrix (ECM)-based powder, composed of modified small intestinal submucos...
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KeAi Communications Co., Ltd.
2025-08-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25001446 |
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| author | Chen-Yu Zou Chen Han Ming Xiong Juan-Juan Hu Yan-Lin Jiang Xiu-Zhen Zhang Ya-Xing Li Long-Mei Zhao Yu-Ting Song Qing-Yi Zhang Qian-Jin Li Rong Nie Yue-Qi Zhang Jesse Li-Ling Hui-Qi Xie |
| author_facet | Chen-Yu Zou Chen Han Ming Xiong Juan-Juan Hu Yan-Lin Jiang Xiu-Zhen Zhang Ya-Xing Li Long-Mei Zhao Yu-Ting Song Qing-Yi Zhang Qian-Jin Li Rong Nie Yue-Qi Zhang Jesse Li-Ling Hui-Qi Xie |
| author_sort | Chen-Yu Zou |
| collection | DOAJ |
| description | Non-compressible hemorrhage poses a severe threat to life globally, yet achieving effective hemostasis and facilitating tissue repair remain a significant challenge and desired requirement. Herein, the all-in-one extracellular matrix (ECM)-based powder, composed of modified small intestinal submucosa (SIS) and sodium alginate, was ingeniously designed to realize one-stop management for non-compressible hemorrhage. Specifically, upon contact bleeding site, the powder's extreme liquid absorption allows for the rapid removal of interfacial blood. Simultaneously, based on the instant self-assembly strategy of covalent/non-covalent interaction, the powder can transform to wet bio-adhesive hydrogel within 5 s, effectively sealing the wound. Using the inherent bioactivities, the ECM-based powder exhibits satisfactory biocompatibility, enhanced cell recruitment, angiogenesis and endothelial cell functions. Ulteriorly, excellent hemostasis performance have verified in rabbit liver non-compressible hemorrhage and heart/artery massive hemorrhage models, significantly reducing the blood loss. More importantly, after hemostasis, the impaired liver demonstrates functional restoration that the more vessels and bile ducts formation, facilitated by the biodegradation of ECM-derived powders in vivo and the multi-biological cues response. Collectively, leveraging the merits of powder and hydrogel, this novel powder fulfills the all-in-one need for both non-compressible hemorrhage control and subsequent tissue repair, signifying it a valuable material in first aid. |
| format | Article |
| id | doaj-art-ed2e603c80fa43adad0dfd65cc4f16fa |
| institution | DOAJ |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-ed2e603c80fa43adad0dfd65cc4f16fa2025-08-20T03:20:15ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-08-015021523110.1016/j.bioactmat.2025.04.005All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repairChen-Yu Zou0Chen Han1Ming Xiong2Juan-Juan Hu3Yan-Lin Jiang4Xiu-Zhen Zhang5Ya-Xing Li6Long-Mei Zhao7Yu-Ting Song8Qing-Yi Zhang9Qian-Jin Li10Rong Nie11Yue-Qi Zhang12Jesse Li-Ling13Hui-Qi Xie14Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR China; Department of Medical Genetics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610093, PR China; Corresponding author. Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.Non-compressible hemorrhage poses a severe threat to life globally, yet achieving effective hemostasis and facilitating tissue repair remain a significant challenge and desired requirement. Herein, the all-in-one extracellular matrix (ECM)-based powder, composed of modified small intestinal submucosa (SIS) and sodium alginate, was ingeniously designed to realize one-stop management for non-compressible hemorrhage. Specifically, upon contact bleeding site, the powder's extreme liquid absorption allows for the rapid removal of interfacial blood. Simultaneously, based on the instant self-assembly strategy of covalent/non-covalent interaction, the powder can transform to wet bio-adhesive hydrogel within 5 s, effectively sealing the wound. Using the inherent bioactivities, the ECM-based powder exhibits satisfactory biocompatibility, enhanced cell recruitment, angiogenesis and endothelial cell functions. Ulteriorly, excellent hemostasis performance have verified in rabbit liver non-compressible hemorrhage and heart/artery massive hemorrhage models, significantly reducing the blood loss. More importantly, after hemostasis, the impaired liver demonstrates functional restoration that the more vessels and bile ducts formation, facilitated by the biodegradation of ECM-derived powders in vivo and the multi-biological cues response. Collectively, leveraging the merits of powder and hydrogel, this novel powder fulfills the all-in-one need for both non-compressible hemorrhage control and subsequent tissue repair, signifying it a valuable material in first aid.http://www.sciencedirect.com/science/article/pii/S2452199X25001446Extracellular matrixWet adhesionSelf-assemblyNon-compressible hemorrhageTissue repair |
| spellingShingle | Chen-Yu Zou Chen Han Ming Xiong Juan-Juan Hu Yan-Lin Jiang Xiu-Zhen Zhang Ya-Xing Li Long-Mei Zhao Yu-Ting Song Qing-Yi Zhang Qian-Jin Li Rong Nie Yue-Qi Zhang Jesse Li-Ling Hui-Qi Xie All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair Bioactive Materials Extracellular matrix Wet adhesion Self-assembly Non-compressible hemorrhage Tissue repair |
| title | All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair |
| title_full | All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair |
| title_fullStr | All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair |
| title_full_unstemmed | All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair |
| title_short | All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair |
| title_sort | all in one extracellular matrix based powders with instant self assembly and multiple bioactivities integrate hemostasis and in situ tissue functional repair |
| topic | Extracellular matrix Wet adhesion Self-assembly Non-compressible hemorrhage Tissue repair |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25001446 |
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