Novel technique of sclerotherapy for superficial lymphatic malformation
PurposeSuperficial lymphatic malformation (SLM), previously known as lymphangioma circumscriptum, is characterized by skin lesions that sometimes require interventional treatment. However, an effective treatment has yet to be established. We proposed an effective sclerotherapy procedure based on the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1614095/full |
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| author | Hidehito Usui Hidehito Usui Masato Shinkai Satoshi Tanaka Rento Morishima Kazuki Shirane Takafumi Kondo Kyoko Mochizuki Norihiko Kitagawa |
| author_facet | Hidehito Usui Hidehito Usui Masato Shinkai Satoshi Tanaka Rento Morishima Kazuki Shirane Takafumi Kondo Kyoko Mochizuki Norihiko Kitagawa |
| author_sort | Hidehito Usui |
| collection | DOAJ |
| description | PurposeSuperficial lymphatic malformation (SLM), previously known as lymphangioma circumscriptum, is characterized by skin lesions that sometimes require interventional treatment. However, an effective treatment has yet to be established. We proposed an effective sclerotherapy procedure based on the pathophysiology of SLM.MethodsSeven patients with SLM who were treated at our hospital between April 2015 and April 2024 were retrospectively enrolled. To maximize the treatment effects, sclerotherapy with bleomycin targeting the SLM and LM deep beneath the SLM was performed.ResultsOf the seven patients, four were females, and three were males. The SLM sites were mucosal lesions in four cases and skin lesions in three cases. The median age at the first sclerotherapy was 10 (1–18) years. A median of one course (1–3) of sclerotherapy resulted in a marked reduction of SLM lesions on gross evaluation to the satisfaction of the patient. The median observation period was 451 (59–2,901) days. No serious complications occurred, except for transient vomiting in one patient and temporary skin pigmentation in two patients. No patient experienced recurrence requiring retreatment.ConclusionOur study suggests that sclerotherapy for the SLM and LM deep beneath the SLM may be an effective treatment for SLM. |
| format | Article |
| id | doaj-art-ed2cf92b37374d7bbb6ecfebc3df689e |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-ed2cf92b37374d7bbb6ecfebc3df689e2025-08-20T03:24:47ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-06-011310.3389/fped.2025.16140951614095Novel technique of sclerotherapy for superficial lymphatic malformationHidehito Usui0Hidehito Usui1Masato Shinkai2Satoshi Tanaka3Rento Morishima4Kazuki Shirane5Takafumi Kondo6Kyoko Mochizuki7Norihiko Kitagawa8Department of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Yokohama City University, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanDepartment of Surgery, Kanagawa Children’s Medical Center, Yokohama, JapanPurposeSuperficial lymphatic malformation (SLM), previously known as lymphangioma circumscriptum, is characterized by skin lesions that sometimes require interventional treatment. However, an effective treatment has yet to be established. We proposed an effective sclerotherapy procedure based on the pathophysiology of SLM.MethodsSeven patients with SLM who were treated at our hospital between April 2015 and April 2024 were retrospectively enrolled. To maximize the treatment effects, sclerotherapy with bleomycin targeting the SLM and LM deep beneath the SLM was performed.ResultsOf the seven patients, four were females, and three were males. The SLM sites were mucosal lesions in four cases and skin lesions in three cases. The median age at the first sclerotherapy was 10 (1–18) years. A median of one course (1–3) of sclerotherapy resulted in a marked reduction of SLM lesions on gross evaluation to the satisfaction of the patient. The median observation period was 451 (59–2,901) days. No serious complications occurred, except for transient vomiting in one patient and temporary skin pigmentation in two patients. No patient experienced recurrence requiring retreatment.ConclusionOur study suggests that sclerotherapy for the SLM and LM deep beneath the SLM may be an effective treatment for SLM.https://www.frontiersin.org/articles/10.3389/fped.2025.1614095/fullsuperficial lymphatic malformationlymphatic malformationsclerotherapybleomycinvascular malformationspediatric surgery |
| spellingShingle | Hidehito Usui Hidehito Usui Masato Shinkai Satoshi Tanaka Rento Morishima Kazuki Shirane Takafumi Kondo Kyoko Mochizuki Norihiko Kitagawa Novel technique of sclerotherapy for superficial lymphatic malformation Frontiers in Pediatrics superficial lymphatic malformation lymphatic malformation sclerotherapy bleomycin vascular malformations pediatric surgery |
| title | Novel technique of sclerotherapy for superficial lymphatic malformation |
| title_full | Novel technique of sclerotherapy for superficial lymphatic malformation |
| title_fullStr | Novel technique of sclerotherapy for superficial lymphatic malformation |
| title_full_unstemmed | Novel technique of sclerotherapy for superficial lymphatic malformation |
| title_short | Novel technique of sclerotherapy for superficial lymphatic malformation |
| title_sort | novel technique of sclerotherapy for superficial lymphatic malformation |
| topic | superficial lymphatic malformation lymphatic malformation sclerotherapy bleomycin vascular malformations pediatric surgery |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1614095/full |
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