Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China
Background. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods. This was a cross-sectional survey in central u...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/9707284 |
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| author | Yanyan Zhao Chunhua Song Xiaokun Ma Xiaojun Ma Qingzhu Wang Hongfei Ji Feng Guo Guijun Qin |
| author_facet | Yanyan Zhao Chunhua Song Xiaokun Ma Xiaojun Ma Qingzhu Wang Hongfei Ji Feng Guo Guijun Qin |
| author_sort | Yanyan Zhao |
| collection | DOAJ |
| description | Background. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods. This was a cross-sectional survey in central urban China (n=1234 patients with T2DM and n=8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index (S) scores. Results. After adjustment for age, gender, BMI, and WHR, a uniparental FHD (OR=2.84, 95% CI: 2.36–3.42, P<0.001), a paternal history of FHD (OR=2.53, 95% CI: 1.91–3.35, P<0.001), a maternal history of FHD (OR=3.27, 95% CI: 2.67–4.02, P<0.001), a biparental history of FHD (OR=5.26, 95% CI: 2.98–9.31, P<0.001), and a FHD, irrespective of the parent (OR=3.59, 95% CI: 3.08–4.17, P<0.001), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes (S=1.54, 95% CI: 1.12–2.12), <8 g/d of poultry (S=1.51, 95% CI: 1.04–2.17), <85 g/d of fresh fruits (S=2.17, 95% CI: 1.63–2.88), and no freshly squeezed juice (S=2.25, 95% CI: 1.46–3.49). Conclusions. Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD. |
| format | Article |
| id | doaj-art-ed23dcbfeb074cae9d0d6f8da7fa1017 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ed23dcbfeb074cae9d0d6f8da7fa10172025-08-20T03:21:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/97072849707284Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central ChinaYanyan Zhao0Chunhua Song1Xiaokun Ma2Xiaojun Ma3Qingzhu Wang4Hongfei Ji5Feng Guo6Guijun Qin7Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDivision of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaBackground. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods. This was a cross-sectional survey in central urban China (n=1234 patients with T2DM and n=8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index (S) scores. Results. After adjustment for age, gender, BMI, and WHR, a uniparental FHD (OR=2.84, 95% CI: 2.36–3.42, P<0.001), a paternal history of FHD (OR=2.53, 95% CI: 1.91–3.35, P<0.001), a maternal history of FHD (OR=3.27, 95% CI: 2.67–4.02, P<0.001), a biparental history of FHD (OR=5.26, 95% CI: 2.98–9.31, P<0.001), and a FHD, irrespective of the parent (OR=3.59, 95% CI: 3.08–4.17, P<0.001), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes (S=1.54, 95% CI: 1.12–2.12), <8 g/d of poultry (S=1.51, 95% CI: 1.04–2.17), <85 g/d of fresh fruits (S=2.17, 95% CI: 1.63–2.88), and no freshly squeezed juice (S=2.25, 95% CI: 1.46–3.49). Conclusions. Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD.http://dx.doi.org/10.1155/2017/9707284 |
| spellingShingle | Yanyan Zhao Chunhua Song Xiaokun Ma Xiaojun Ma Qingzhu Wang Hongfei Ji Feng Guo Guijun Qin Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China International Journal of Endocrinology |
| title | Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China |
| title_full | Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China |
| title_fullStr | Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China |
| title_full_unstemmed | Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China |
| title_short | Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China |
| title_sort | synergistic effect of family history of diabetes and dietary habits on the risk of type 2 diabetes in central china |
| url | http://dx.doi.org/10.1155/2017/9707284 |
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