Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation

Abstract Protein kinase AKT plays a broad role in promoting energy production in nutrient-rich environments. However, its roles under metabolic stress remain elusive. Herein, we demonstrate a dual mechanism for AKT activation during glucose deprivation. On one hand, glucose deprivation leads to incr...

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Bibliographic Details
Main Authors: Guang-xi Yang, De-liang Peng, Lin Chen, Yu Qian, Le He, Xiao-yan Chen, Wen-bin Hong, Cai-ming Wu, Hang-zi Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07906-4
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