Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report
Medullary thyroid cancer (MTC) is a rare disorder that accounts for approximately 1.7 % of all thyroid malignancies. MTC is usually detected at early stages; however, approximately 10–15 % of patients are diagnosed with locally advanced MTC and distant metastases. Treatment of such patients is chall...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2019-10-01
|
| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/421 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403877255806976 |
|---|---|
| author | А. М. Mudunov Yu. V. Alymov I. S. Romanov S. О. Podvyaznikov А. V. Ignatova |
| author_facet | А. М. Mudunov Yu. V. Alymov I. S. Romanov S. О. Podvyaznikov А. V. Ignatova |
| author_sort | А. М. Mudunov |
| collection | DOAJ |
| description | Medullary thyroid cancer (MTC) is a rare disorder that accounts for approximately 1.7 % of all thyroid malignancies. MTC is usually detected at early stages; however, approximately 10–15 % of patients are diagnosed with locally advanced MTC and distant metastases. Treatment of such patients is challenging due to biological characteristics of the disease and very few effective treatment approaches available. The investigation of mechanisms of carcinogenesis, as well as advances in pharmacology, allowed the development of a new group of targeted drugs, namely tyrosine kinases, which efficacy against progressive unresectable locally advanced or metastatic MTC has been demonstrated in multiple clinical trials. Vandetanib has been registered for MTC treatment in the Russian Federation. MTC is very rare, thus, each case of vandetanib use for its treatment is particularly interesting. Moreover, since the approval of this drug in 2011 by the U. S. Food and Drug Administration (FDA), new data on the clinical use of vandetanib have been accumulated. Importantly, clinical trials are usually well designed and conducted in near-ideal conditions, whereas the real conditions can be different and patients may have individual characteristics. Therefore, the aim of this study was to update the information on the efficacy and safety of vandetanib by retrospective analysis of available publications and to report a case of MTC treated with vandetanib. |
| format | Article |
| id | doaj-art-ed1734a8fb0b4f809ad2f832f64fed0a |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2019-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-ed1734a8fb0b4f809ad2f832f64fed0a2025-08-20T03:37:09ZrusABV-pressОпухоли головы и шеи2222-14682411-46342019-10-0193384810.17650/2222-1468-2019-9-3-38-48357Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case reportА. М. Mudunov0Yu. V. Alymov1I. S. Romanov2S. О. Podvyaznikov3А. V. Ignatova4N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaRussian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; RUDN UniversityMedullary thyroid cancer (MTC) is a rare disorder that accounts for approximately 1.7 % of all thyroid malignancies. MTC is usually detected at early stages; however, approximately 10–15 % of patients are diagnosed with locally advanced MTC and distant metastases. Treatment of such patients is challenging due to biological characteristics of the disease and very few effective treatment approaches available. The investigation of mechanisms of carcinogenesis, as well as advances in pharmacology, allowed the development of a new group of targeted drugs, namely tyrosine kinases, which efficacy against progressive unresectable locally advanced or metastatic MTC has been demonstrated in multiple clinical trials. Vandetanib has been registered for MTC treatment in the Russian Federation. MTC is very rare, thus, each case of vandetanib use for its treatment is particularly interesting. Moreover, since the approval of this drug in 2011 by the U. S. Food and Drug Administration (FDA), new data on the clinical use of vandetanib have been accumulated. Importantly, clinical trials are usually well designed and conducted in near-ideal conditions, whereas the real conditions can be different and patients may have individual characteristics. Therefore, the aim of this study was to update the information on the efficacy and safety of vandetanib by retrospective analysis of available publications and to report a case of MTC treated with vandetanib.https://ogsh.abvpress.ru/jour/article/view/421medullary thyroid cancertargeted therapymetastasestyrosine kinase inhibitorsvandetanib |
| spellingShingle | А. М. Mudunov Yu. V. Alymov I. S. Romanov S. О. Podvyaznikov А. V. Ignatova Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report Опухоли головы и шеи medullary thyroid cancer targeted therapy metastases tyrosine kinase inhibitors vandetanib |
| title | Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report |
| title_full | Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report |
| title_fullStr | Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report |
| title_full_unstemmed | Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report |
| title_short | Efficacy of vandetanib in the treatment of medullary thyroid cancer: literature review and case report |
| title_sort | efficacy of vandetanib in the treatment of medullary thyroid cancer literature review and case report |
| topic | medullary thyroid cancer targeted therapy metastases tyrosine kinase inhibitors vandetanib |
| url | https://ogsh.abvpress.ru/jour/article/view/421 |
| work_keys_str_mv | AT ammudunov efficacyofvandetanibinthetreatmentofmedullarythyroidcancerliteraturereviewandcasereport AT yuvalymov efficacyofvandetanibinthetreatmentofmedullarythyroidcancerliteraturereviewandcasereport AT isromanov efficacyofvandetanibinthetreatmentofmedullarythyroidcancerliteraturereviewandcasereport AT sopodvyaznikov efficacyofvandetanibinthetreatmentofmedullarythyroidcancerliteraturereviewandcasereport AT avignatova efficacyofvandetanibinthetreatmentofmedullarythyroidcancerliteraturereviewandcasereport |