Myasthenia gravis in clinical practice
ABSTRACT Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the ma...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2022-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700257&tlng=en |
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| author | Eduardo de Paula Estephan José Pedro Soares Baima Antonio Alberto Zambon |
| author_facet | Eduardo de Paula Estephan José Pedro Soares Baima Antonio Alberto Zambon |
| author_sort | Eduardo de Paula Estephan |
| collection | DOAJ |
| description | ABSTRACT Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients. Methods: The authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis. Results: Most patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease. Conclusion: Knowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care. |
| format | Article |
| id | doaj-art-ed12bf3b5799478ba4736dd7f2e7f485 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-ed12bf3b5799478ba4736dd7f2e7f4852025-08-20T03:06:30ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272022-08-01805 suppl 125726510.1590/0004-282x-anp-2022-s105Myasthenia gravis in clinical practiceEduardo de Paula Estephanhttps://orcid.org/0000-0002-6807-1951José Pedro Soares Baimahttps://orcid.org/0000-0003-2708-1181Antonio Alberto Zambonhttps://orcid.org/0000-0002-5323-3778ABSTRACT Background: Myasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients. Methods: The authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis. Results: Most patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease. Conclusion: Knowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700257&tlng=enMyasthenia GravisNeuromuscular JunctionNeuromuscular DiseasesNeuromuscular Junction DiseasesPractice Guideline |
| spellingShingle | Eduardo de Paula Estephan José Pedro Soares Baima Antonio Alberto Zambon Myasthenia gravis in clinical practice Arquivos de Neuro-Psiquiatria Myasthenia Gravis Neuromuscular Junction Neuromuscular Diseases Neuromuscular Junction Diseases Practice Guideline |
| title | Myasthenia gravis in clinical practice |
| title_full | Myasthenia gravis in clinical practice |
| title_fullStr | Myasthenia gravis in clinical practice |
| title_full_unstemmed | Myasthenia gravis in clinical practice |
| title_short | Myasthenia gravis in clinical practice |
| title_sort | myasthenia gravis in clinical practice |
| topic | Myasthenia Gravis Neuromuscular Junction Neuromuscular Diseases Neuromuscular Junction Diseases Practice Guideline |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700257&tlng=en |
| work_keys_str_mv | AT eduardodepaulaestephan myastheniagravisinclinicalpractice AT josepedrosoaresbaima myastheniagravisinclinicalpractice AT antonioalbertozambon myastheniagravisinclinicalpractice |