The Progress of Methylation Regulation in Gene Expression of Cervical Cancer
Cervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection. Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/8260652 |
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| _version_ | 1850163799050420224 |
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| author | Chunyang Feng Junxue Dong Weiqin Chang Manhua Cui Tianmin Xu |
| author_facet | Chunyang Feng Junxue Dong Weiqin Chang Manhua Cui Tianmin Xu |
| author_sort | Chunyang Feng |
| collection | DOAJ |
| description | Cervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection. Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression of cervical cancer in pathogenesis while reflecting the prognosis and therapeutic sensitivity in clinical practice. Hydroxymethylation has been discovered in recent years, thus making 5-hmC, the more stable marker, attract more attention in the field of methylation research. As markers of methylation, 5-hmC and 5-mC together with 5-foC and 5-caC draw the outline of the reversible cycle, and 6-mA takes part in the methylation of RNA, especially mRNA. Furthermore, methylation modification participates in ncRNA regulation and histone decoration. In this review, we focus on recent advances in the understanding of methylation regulation in the process of cervical cancer, as well as HPV and CIN, to identify the significant impact on the prospect of overcoming cervical cancer. |
| format | Article |
| id | doaj-art-ed0e6f4ca35e43f38f4ca05db1f3fe69 |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-ed0e6f4ca35e43f38f4ca05db1f3fe692025-08-20T02:22:09ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/82606528260652The Progress of Methylation Regulation in Gene Expression of Cervical CancerChunyang Feng0Junxue Dong1Weiqin Chang2Manhua Cui3Tianmin Xu4The Second Hospital of Jilin University, Jilin, Changchun 130041, ChinaThe Second Hospital of Jilin University, Jilin, Changchun 130041, ChinaThe Second Hospital of Jilin University, Jilin, Changchun 130041, ChinaThe Second Hospital of Jilin University, Jilin, Changchun 130041, ChinaThe Second Hospital of Jilin University, Jilin, Changchun 130041, ChinaCervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection. Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression of cervical cancer in pathogenesis while reflecting the prognosis and therapeutic sensitivity in clinical practice. Hydroxymethylation has been discovered in recent years, thus making 5-hmC, the more stable marker, attract more attention in the field of methylation research. As markers of methylation, 5-hmC and 5-mC together with 5-foC and 5-caC draw the outline of the reversible cycle, and 6-mA takes part in the methylation of RNA, especially mRNA. Furthermore, methylation modification participates in ncRNA regulation and histone decoration. In this review, we focus on recent advances in the understanding of methylation regulation in the process of cervical cancer, as well as HPV and CIN, to identify the significant impact on the prospect of overcoming cervical cancer.http://dx.doi.org/10.1155/2018/8260652 |
| spellingShingle | Chunyang Feng Junxue Dong Weiqin Chang Manhua Cui Tianmin Xu The Progress of Methylation Regulation in Gene Expression of Cervical Cancer International Journal of Genomics |
| title | The Progress of Methylation Regulation in Gene Expression of Cervical Cancer |
| title_full | The Progress of Methylation Regulation in Gene Expression of Cervical Cancer |
| title_fullStr | The Progress of Methylation Regulation in Gene Expression of Cervical Cancer |
| title_full_unstemmed | The Progress of Methylation Regulation in Gene Expression of Cervical Cancer |
| title_short | The Progress of Methylation Regulation in Gene Expression of Cervical Cancer |
| title_sort | progress of methylation regulation in gene expression of cervical cancer |
| url | http://dx.doi.org/10.1155/2018/8260652 |
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