Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway
Abstract Chronic inflammation is a critical mechanism contributing to the aging process; however, research specifically addressing chronic inflammation in skin biology remains limited. This study investigates the protective mechanism of Rosa roxburghii Tratt. (RRT) extract against UVB-induced inflam...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-92559-8 |
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| author | Shuhong Zhang Yueyue Chen Liping Qu |
| author_facet | Shuhong Zhang Yueyue Chen Liping Qu |
| author_sort | Shuhong Zhang |
| collection | DOAJ |
| description | Abstract Chronic inflammation is a critical mechanism contributing to the aging process; however, research specifically addressing chronic inflammation in skin biology remains limited. This study investigates the protective mechanism of Rosa roxburghii Tratt. (RRT) extract against UVB-induced inflammaging. RRT extract effectively reduces the secretion of IL-6, IL-1α, TNF-α, and PGE2 in keratinocytes. Additionally, it attenuates UVB-induced IL-17 pathway activation by downregulating IL-17RA, c-Fos, and c-Jun protein levels, as well as the gene expression of IL-17RA, TRAF6, HSP90, and IKKγ. Co-culturing human foreskin fibroblasts (HFF) with inflammatory factors secreted by UVB-exposed keratinocytes reveals that these factors significantly reduce mitochondrial membrane potential and mitochondrial reactive oxygen species (ROS), thereby promoting aging in HFF. The anti-inflammaging effects of RRT extract are achieved through the reduction of β-galactosidase activity, targeting of the TGF-β1-Smad2/3 signaling pathway, upregulation of COL1A1 expression, and reduction of senescence-associated secretory phenotype secretion. This study provides a novel perspective and robust scientific foundation for exploring mechanisms of skin aging and potential therapeutic interventions. |
| format | Article |
| id | doaj-art-ed0dd0315d6f4134a4ccc8984805e541 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-ed0dd0315d6f4134a4ccc8984805e5412025-08-20T03:02:19ZengNature PortfolioScientific Reports2045-23222025-03-0115111210.1038/s41598-025-92559-8Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathwayShuhong Zhang0Yueyue Chen1Liping Qu2Yunnan Botanee Bio-Technology Group Co., Ltd.Yunnan Botanee Bio-Technology Group Co., Ltd.Yunnan Botanee Bio-Technology Group Co., Ltd.Abstract Chronic inflammation is a critical mechanism contributing to the aging process; however, research specifically addressing chronic inflammation in skin biology remains limited. This study investigates the protective mechanism of Rosa roxburghii Tratt. (RRT) extract against UVB-induced inflammaging. RRT extract effectively reduces the secretion of IL-6, IL-1α, TNF-α, and PGE2 in keratinocytes. Additionally, it attenuates UVB-induced IL-17 pathway activation by downregulating IL-17RA, c-Fos, and c-Jun protein levels, as well as the gene expression of IL-17RA, TRAF6, HSP90, and IKKγ. Co-culturing human foreskin fibroblasts (HFF) with inflammatory factors secreted by UVB-exposed keratinocytes reveals that these factors significantly reduce mitochondrial membrane potential and mitochondrial reactive oxygen species (ROS), thereby promoting aging in HFF. The anti-inflammaging effects of RRT extract are achieved through the reduction of β-galactosidase activity, targeting of the TGF-β1-Smad2/3 signaling pathway, upregulation of COL1A1 expression, and reduction of senescence-associated secretory phenotype secretion. This study provides a novel perspective and robust scientific foundation for exploring mechanisms of skin aging and potential therapeutic interventions.https://doi.org/10.1038/s41598-025-92559-8InflammagingInflammatory factorsKeratinocytesHuman foreskin fibroblastsIL-17 signal pathwayRosa. roxburghii Tratt. |
| spellingShingle | Shuhong Zhang Yueyue Chen Liping Qu Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway Scientific Reports Inflammaging Inflammatory factors Keratinocytes Human foreskin fibroblasts IL-17 signal pathway Rosa. roxburghii Tratt. |
| title | Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway |
| title_full | Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway |
| title_fullStr | Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway |
| title_full_unstemmed | Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway |
| title_short | Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway |
| title_sort | protective effects of rosa roxburghii tratt extract against uvb induced inflammaging through inhibiting the il 17 pathway |
| topic | Inflammaging Inflammatory factors Keratinocytes Human foreskin fibroblasts IL-17 signal pathway Rosa. roxburghii Tratt. |
| url | https://doi.org/10.1038/s41598-025-92559-8 |
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