8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate

We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3a</b>) and 8-iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3b</b>) in good yields through an <i>O</i>-sulfo...

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Main Authors: Luis Pulido-Moreno, Andrés Parra-Tibocha, Alexander Ladino-Bejarano, Mario A. Macías, Diana Becerra, Juan-Carlos Castillo
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Molbank
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Online Access:https://www.mdpi.com/1422-8599/2024/3/M1869
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author Luis Pulido-Moreno
Andrés Parra-Tibocha
Alexander Ladino-Bejarano
Mario A. Macías
Diana Becerra
Juan-Carlos Castillo
author_facet Luis Pulido-Moreno
Andrés Parra-Tibocha
Alexander Ladino-Bejarano
Mario A. Macías
Diana Becerra
Juan-Carlos Castillo
author_sort Luis Pulido-Moreno
collection DOAJ
description We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3a</b>) and 8-iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3b</b>) in good yields through an <i>O</i>-sulfonylation reaction of 7-hydroxy-2<i>H</i>-chromen-2-ones <b>1a</b> and <b>1b</b> with benzenesulfonyl chloride <b>2</b> mediated by triethylamine in dichloromethane at ambient temperature. The aryl sulfonyl esters were characterized using spectroscopic, spectrometric, and thermal analyses.
format Article
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institution OA Journals
issn 1422-8599
language English
publishDate 2024-08-01
publisher MDPI AG
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series Molbank
spelling doaj-art-ed081e86f6cc4e81aee88a0ee69039112025-08-20T01:55:42ZengMDPI AGMolbank1422-85992024-08-0120243M186910.3390/M18698-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl BenzenesulfonateLuis Pulido-Moreno0Andrés Parra-Tibocha1Alexander Ladino-Bejarano2Mario A. Macías3Diana Becerra4Juan-Carlos Castillo5Electiva Disciplinar V, Espectrometría de Masas, Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja 150003, ColombiaElectiva Disciplinar V, Espectrometría de Masas, Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja 150003, ColombiaElectiva Disciplinar V, Espectrometría de Masas, Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja 150003, ColombiaCristalografía y Química de Materiales, CrisQuimMat, Departamento de Química, Universidad de los Andes, Carrera 1 No. 18A-10, Bogotá 111711, ColombiaElectiva de Profundización II, Síntesis y Caracterización de Compuestos Heterocíclicos, Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja 150003, ColombiaElectiva Disciplinar V, Espectrometría de Masas, Escuela de Ciencias Químicas, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja 150003, ColombiaWe report a straightforward and efficient synthesis of 4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3a</b>) and 8-iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3b</b>) in good yields through an <i>O</i>-sulfonylation reaction of 7-hydroxy-2<i>H</i>-chromen-2-ones <b>1a</b> and <b>1b</b> with benzenesulfonyl chloride <b>2</b> mediated by triethylamine in dichloromethane at ambient temperature. The aryl sulfonyl esters were characterized using spectroscopic, spectrometric, and thermal analyses.https://www.mdpi.com/1422-8599/2024/3/M1869coumarinaryl sulfonyl ester<i>O</i>-sulfonylation reaction
spellingShingle Luis Pulido-Moreno
Andrés Parra-Tibocha
Alexander Ladino-Bejarano
Mario A. Macías
Diana Becerra
Juan-Carlos Castillo
8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
Molbank
coumarin
aryl sulfonyl ester
<i>O</i>-sulfonylation reaction
title 8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
title_full 8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
title_fullStr 8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
title_full_unstemmed 8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
title_short 8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate
title_sort 8 iodo 4 methyl 2 oxo 2 i h i chromen 7 yl benzenesulfonate
topic coumarin
aryl sulfonyl ester
<i>O</i>-sulfonylation reaction
url https://www.mdpi.com/1422-8599/2024/3/M1869
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AT marioamacias 8iodo4methyl2oxo2ihichromen7ylbenzenesulfonate
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