8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate

8-Iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl Benzenesulfonate

We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3a</b>) and 8-iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3b</b>) in good yields through an <i>O</i>-sulfo...

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Bibliographic Details
Main Authors:	Luis Pulido-Moreno, Andrés Parra-Tibocha, Alexander Ladino-Bejarano, Mario A. Macías, Diana Becerra, Juan-Carlos Castillo
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Series:	Molbank
Subjects:	coumarin aryl sulfonyl ester <i>O</i>-sulfonylation reaction
Online Access:	https://www.mdpi.com/1422-8599/2024/3/M1869
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Summary:	We report a straightforward and efficient synthesis of 4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3a</b>) and 8-iodo-4-methyl-2-oxo-2<i>H</i>-chromen-7-yl benzenesulfonate (<b>3b</b>) in good yields through an <i>O</i>-sulfonylation reaction of 7-hydroxy-2<i>H</i>-chromen-2-ones <b>1a</b> and <b>1b</b> with benzenesulfonyl chloride <b>2</b> mediated by triethylamine in dichloromethane at ambient temperature. The aryl sulfonyl esters were characterized using spectroscopic, spectrometric, and thermal analyses.
ISSN:	1422-8599